ArticleClinical neuroradiology2010
Toxic leukoencephalopathy after heroin abuse without heroin vapor inhalation: MR imaging and clinical features in three patients.
Article in Clinical neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: A systematic review.Drug and alcohol dependence · 2021Pooled it
- Toxic Leukoencephalopathy due to Suspected Levamisole-adulterated Cocaine.Clinical neuroradiology · 2024Article
- Clinical and neuroradiographic features of fentanyl inhalation-induced leukoencephalopathy.BMJ case reports · 2024Article
- Partial Recovery in Toxic Leukoencephalopathy: Is It Really a Slow Improvement or a Warning Sign?Cureus · 2023Article
- Leukoencephalopathy due to inhalational and trans-conjunctival heroin abuse: First case report from Pakistan.Annals of medicine and surgery (2012) · 2022Article
- Serious health threats of novel adulterants of the street heroin: a report from India during the COVID-19 pandemic.BMJ case reports · 2021Article
- Posterior Reversible Encephalopathy Syndrome (PRES) in a Patient with Opioid Use Disorder.Case reports in psychiatry · 2021Article
- Different routes of heroin intake cause various heroin-induced leukoencephalopathies.Journal of neurology · 2019Article
- Toxic leucoencephalopathy after 'chasing the dragon'.Singapore medical journal · 2015Article
- Differential diagnosis of white matter lesions: Nonvascular causes-Part II.Clinical neuroradiology · 2014Review
- Selective injury of the globus pallidus and hippocampus in methamphetamine-induced encephalopathy.Clinical neuroradiology · 2013Article
- Heroin spongiform leukoencephalopathy (HSLE).Clinical neuroradiology · 2012Article
- Toxic leukoencephalopathy after intravenous heroin injection: a case with clinical and radiological reversibility.Journal of neurology · 2010Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeToxic leukoencephalopathy has been associated with illicit heroin vapor inhalation. Despite the nonspecific and variable clinical presentation of these patients, they show typical radiologic findings. Previous studies evaluated typical radiologic findings with symmetric infratentorial hyperintense signal changes and similar alteration in the posterior limb of the internal capsule, the splenium of corpus callosum, the medial lemniscus and the lateral brainstem. In context with the reviewed literature, a series of another three cases with toxic leukoencephalopathy after heroin abuse other than vapor inhalation is presented. PATIENTS AND
methodsAll three patients underwent magnet resonance imaging (MRI) including additional diffusion- weighted imaging and apparent diffusion coefficient maps. Clinical and laboratory findings were recorded.
resultsMRI of all three patients revealed similar symmetric supratentorial hyperintense signal changes involving the frontal, parietal, occipital and temporal lobes. The cortex was spared and the subcortical U fibers were partially involved. Further, the brainstem and the cerebellar white matter were not affected.
conclusionToxic leukoencephalopathy without involvement of the cerebellum and brainstem is a rare complication of heroin abuse. The pattern of heroin-induced toxic leukoencephalopathy on MRI might not only be related to an unknown adulterant, but also to the mode of drug administration.
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