ArticleJournal of materials science. Materials in medicine2010
The stability mechanisms of an injectable calcium phosphate ceramic suspension.
Article in Journal of materials science. Materials in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Morphological and Rheological Analysis of an Injectable Calcium Hydroxylapatite Dermal Filler with Lattice-Pore Surface Architecture.Journal of functional biomaterials · 2026Article
- A 25-Year Review of the Use of Silanized Hydroxypropylmethylcellulose Hydrogels in Tissue Engineering and Regenerative Medicine.Macromolecular bioscience · 2026Review
- Preparation of a (Ca,Sr,Ba)ZrOMaterials (Basel, Switzerland) · 2024Article
- Advanced Hydrogel-Based Strategies for Enhanced Bone and Cartilage Regeneration: A Comprehensive Review.Gels (Basel, Switzerland) · 2023Review
- Cefquinome Sulfate Oily Nanosuspension Designed for Improving its Bioavailability in the Treatment of Veterinary Infections.International journal of nanomedicine · 2022Article
- Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization.Journal of nanobiotechnology · 2021Article
- Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.Nano-micro letters · 2020Article
- Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications.Journal of functional biomaterials · 2015Review
- Improved Sterilization of Sensitive Biomaterials with Supercritical Carbon Dioxide at Low Temperature.PloS one · 2015Article
- Injection of calcium phosphate pastes: prediction of injection force and comparison with experiments.Journal of materials science. Materials in medicine · 2012Article
- Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium phosphate ceramics are widely used as bone substitutes in dentistry and orthopedic applications. For minimally invasive surgery an injectable calcium phosphate ceramic suspension (ICPCS) was developed. It consists in a biopolymer (hydroxypropylmethylcellulose: HPMC) as matrix and bioactive calcium phosphate ceramics (biphasic calcium phosphate: BCP) as fillers. The stability of the suspension is essential to this generation of "ready to use" injectable biomaterial. But, during storage, the particles settle down. The engineering sciences have long been interested in models describing the settling (or sedimentation) of particles in viscous fluids. Our work is dedicated to the comprehension of the effect of the formulation on the stability of calcium phosphate suspension before and after steam sterilization. The rheological characterization revealed the macromolecular behavior of the suspending medium. The investigations of settling kinetics showed the influence of the BCP particle size and the HPMC concentration on the settling velocity and sediment compactness before and after sterilization. To decrease the sedimentation process, the granule size has to be smaller and the polymer concentration has to increase. A much lower sedimentation velocity, as compared to Stokes law, is observed and interpreted in terms of interactions between the polymer network in solution and the particles. This experimentation highlights the granules spacer property of hydrophilic macromolecules that is a key issue for interconnection control, one of the better ways to improve osteoconduction and bioactivity.
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