ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2010
Place memory formation in Drosophila is independent of proper octopamine signaling.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Octopamine receptors inFrontiers in molecular neuroscience · 2026Article
- Control of Aedes albopictus populations by silencing of the vesicular GABA transporter (vgat) and the vesicular monoamine transporter (vmat) genes using recombinant Chlorella shRNA.Parasites & vectors · 2025Article
- Multiple genetic loci affect place learning and memory performance in Drosophila melanogaster.Genes, brain, and behavior · 2019Article
- MARGO (Massively Automated Real-time GUI for Object-tracking), a platform for high-throughput ethology.PloS one · 2019Article
- A biphasic locomotor response to acute unsignaled high temperature exposure in Drosophila.PloS one · 2018Article
- Discrete Serotonin Systems Mediate Memory Enhancement and Escape Latencies after Unpredicted Aversive Experience inFrontiers in systems neuroscience · 2017Article
- Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster.Genetics · 2013Article
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- Use of spatial information and search strategies in a water maze analog in Drosophila melanogaster.PloS one · 2010Article
- Short-term memories in Drosophila are governed by general and specific genetic systems.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Review
- A Neurogenetic Dissociation between Punishment-, Reward-, and Relief-Learning in Drosophila.Frontiers in behavioral neuroscience · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biogenic amines play a critical role in establishing memories. In the insects, octopamine, dopamine, and serotonin have key functions in memory formation. For Drosophila, octopamine is necessary and sufficient for appetitive olfactory memory formation. Whether octopamine plays a general role in reinforcing memories in the fly is not known. Place learning in the heat-box associates high temperatures with one part of a narrow chamber, and a cool, strongly preferred temperature with the other half of the chamber. The cool-temperature-associated chamber half could provide a rewarding stimulus to a fly, and thus a place memory is composed of an aversive and rewarded memory component. The role of octopamine in place memory was thus tested. Using a mutation in the tyramine beta hydroxylase (TbetaH[M18]) and blocking of evoked synaptic transmission in the octopamine (and tyramine) neurons labeled with a tyramine decarboxylase-2 (TDC2) gene regulatory elements we found that reinforcement of place memories is independent of normal octopamine signaling. Thus, reinforcing mechanisms in Drosophila have specialized systems in the formation of specific memory types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.