ArticleNature nanotechnology2010
Kinetics of antimicrobial peptide activity measured on individual bacterial cells using high-speed atomic force microscopy.
Article in Nature nanotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
125 citing papers in PubMed.
- Investigation of Bacterial Curli Production and Adhesion Using AFM.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Advances in scanning probe microscopy for biological systems.Biophysics reports · 2026Article
- Article
- Article
- Total Chemical Synthesis and Evaluation of the Antimicrobial Properties of Porcine β-Defensin 5 Against Gram-Positive and Gram-Negative Bacteria.Probiotics and antimicrobial proteins · 2026Article
- Review
- Zooming into Disease at the Nanoscale: High-Speed Atomic Force Microscopy in Biomedical Discovery.ACS nano · 2026Review
- AMPSeek: A Workflow for Predicting Antimicrobial Peptide Activity, Three-Dimensional Structure, and Toxicity.Current protocols · 2026Article
- Lipidated peptides and the limits of chemical control.Frontiers in chemistry · 2026Article
- Antimicrobial peptide prediction based on contrastive learning and gated convolutional neural network.Scientific reports · 2025Article
- Testing antimicrobial peptides inhibiting protein synthesis in livingFrontiers in microbiology · 2025Article
- Peptide-Membrane Docking and Molecular Dynamic Simulation of In Silico Detected Antimicrobial Peptides from Portulaca oleracea's Transcriptome.Probiotics and antimicrobial proteins · 2024Article
- Multiple resistance factors collectively promote inoculum-dependent dynamic survival during antimicrobial peptide exposure in Enterobacter cloacae.PLoS pathogens · 2024Article
- Unveiling the mechanism of essential oil action against skin pathogens: from ancient wisdom to modern science.Archives of microbiology · 2024Review
- Quantifying massively parallel microbial growth with spatially mediated interactions.PLoS computational biology · 2024Article
- Employment of mastoparan-like peptides to preventJournal of bacteriology · 2024Article
- Multiple resistance factors collectively promote inoculum-dependent dynamic survival during antimicrobial peptide exposure inbioRxiv : the preprint server for biology · 2024Article
- Mechanical morphotype switching as an adaptive response in mycobacteria.Science advances · 2024Article
- Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography.Nature communications · 2023Article
- The effect of metalation on antimicrobial piscidins imbedded in normal and oxidized lipid bilayers.RSC chemical biology · 2023Article
65 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Observations of real-time changes in living cells have contributed much to the field of cellular biology. The ability to image whole, living cells with nanometre resolution on a timescale that is relevant to dynamic cellular processes has so far been elusive. Here, we investigate the kinetics of individual bacterial cell death using a novel high-speed atomic force microscope optimized for imaging live cells in real time. The increased time resolution (13 s per image) allows the characterization of the initial stages of the action of the antimicrobial peptide CM15 on individual Escherichia coli cells with nanometre resolution. Our results indicate that the killing process is a combination of a time-variable incubation phase (which takes seconds to minutes to complete) and a more rapid execution phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.