ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2010
Spatiotemporal dynamics of Ca2+ signaling and its physiological roles.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- The CAGE Framework (Calcium-Gated Excitability): From Single Neurotransmitters to Calcium States in the Tumor Microenvironment.International journal of molecular sciences · 2026Review
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- The Multifaceted Role of Calcium Signaling in Regulated Necrosis.Biomolecules · 2025Review
- Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Skeletal and cardiac muscle calcium transport regulation in health and disease.Bioscience reports · 2022Review
- Missense mutations in inositol 1,4,5-trisphosphate receptor type 3 result in leaky CaiScience · 2022Article
- Application of Optogenetics for Muscle Cells and Stem Cells.Advances in experimental medicine and biology · 2021Article
- Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function.The Journal of biological chemistry · 2020Article
- Activation of calcium‑sensing receptor‑mediated autophagy in high glucose‑induced cardiac fibrosis in vitro.Molecular medicine reports · 2020Article
- Purinergic signalling in a latent stem cell niche of the rat spinal cord.Purinergic signalling · 2016Article
- Organelle reorganization in bovine oocytes during dominant follicle growth and regression.Reproductive biology and endocrinology : RB&E · 2015Article
- Tracing the Evolutionary History of Inositol, 1, 4, 5-Trisphosphate Receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs.Molecular biology and evolution · 2015Article
- Modelling mechanism of calcium oscillations in pancreatic acinar cells.Journal of bioenergetics and biomembranes · 2014Article
- A G-protein subunit translocation embedded network motif underlies GPCR regulation of calcium oscillations.Biophysical journal · 2014Article
- Modelling the transition from simple to complex Ca²⁺ oscillations in pancreatic acinar cells.Journal of biosciences · 2014Article
- Article
- Understanding calcium waves and sparks in central neurons.Nature reviews. Neuroscience · 2012Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in the intracellular Ca(2+) concentration regulate numerous cell functions and display diverse spatiotemporal dynamics, which underlie the versatility of Ca(2+) in cell signaling. In many cell types, an increase in the intracellular Ca(2+) concentration starts locally, propagates within the cell (Ca(2+) wave) and makes oscillatory changes (Ca(2+) oscillation). Studies of the intracellular Ca(2+) release mechanism from the endoplasmic reticulum (ER) showed that the Ca(2+) release mechanism has inherent regenerative properties, which is essential for the generation of Ca(2+) waves and oscillations. Ca(2+) may shuttle between the ER and mitochondria, and this appears to be important for pacemaking of Ca(2+) oscillations. Importantly, Ca(2+) oscillations are an efficient mechanism in regulating cell functions, having effects supra-proportional to the sum of duration of Ca(2+) increase. Furthermore, Ca(2+) signaling mechanism studies have led to the development of a method for specific inhibition of Ca(2+) signaling, which has been used to identify hitherto unrecognized functions of Ca(2+) signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.