ArticleJournal of lipid research2010
The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality.
Article in Journal of lipid research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Pooled it
- Plant sterols and cardiovascular disease: a systematic review and meta-analysis.European heart journal · 2012Pooled it
- Plant Sterol-Enriched Palm Oil Intervention to Improve Lipid Profile and Inflammation Status in Hyperlipidemic Individuals.Nutrients · 2024Trial
- Exploring the effect of vitamin D3 supplementation on surrogate biomarkers of cholesterol absorption and endogenous synthesis in patients with type 2 diabetes-randomized controlled trial.The American journal of clinical nutrition · 2020Trial
- Genomics of post-prandial lipidomic phenotypes in the Genetics of Lipid lowering Drugs and Diet Network (GOLDN) study.PloS one · 2014Trial
- Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans.Experimental diabetes research · 2012Trial
- Causal relationship between circulating plasma lipids and atopic dermatitis risk: potential drug targets and therapeutic strategies.Archives of dermatological research · 2024Article
- Genotype-based "virtual" metabolomics in a clinical biobank identifies novel metabolite-disease associations.Frontiers in genetics · 2024Article
- Genotype-based "virtual" metabolomics in a clinical biobank identifies novel metabolite-disease associations.Research square · 2023Article
- Remnant cholesterol, but not other cholesterol parameters, is associated with gestational diabetes mellitus in pregnant women: a prospective cohort study.Journal of translational medicine · 2023Article
- Plant Sterols and Plant Stanols in Cholesterol Management and Cardiovascular Prevention.Nutrients · 2023Review
- Phytosterols and Cardiovascular Risk Evaluated against the Background of Phytosterolemia Cases-A German Expert Panel Statement.Nutrients · 2023Article
- Plant sterol hyperabsorption caused by uncontrolled diabetes in a patient with a heterozygous ABCG5 variant.Journal of diabetes investigation · 2022Article
- Phytosterols and Cardiovascular Disease.Current atherosclerosis reports · 2021Review
- Cross-Sectional Study of Plant Sterols Intake as a Basis for Designing Appropriate Plant Sterol-Enriched Food in Indonesia.Nutrients · 2021Article
- The coronary artery calcium score is linked to plasma cholesterol synthesis and absorption markers: Brazilian Longitudinal Study of Adult Health.Bioscience reports · 2020Article
- Endothelial Nitric Oxide Mediates the Anti-Atherosclerotic Action ofInternational journal of molecular sciences · 2020Article
- Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels.Frontiers in pharmacology · 2020Review
- Low serum lathosterol levels associate with fatal cardiovascular disease and excess all-cause mortality: a prospective cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- The intestinal microbiota regulates host cholesterol homeostasis.BMC biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moderately elevated levels of plasma plant sterols have been suspected to be causally involved in atherosclerosis. The aim of this study was to investigate whether plant sterols and other markers of sterol metabolism predicted all-cause and cardiovascular mortality in participants of the Ludwigshafen Risk and Cardiovascular health (LURIC) study. A total of 1,257 individuals who did not use statins and at baseline had a mean (+/- SD) age of 62.8 (+/- 11.0) years were included in the present analysis. Lathosterol, cholestanol, campesterol, and sitosterol were measured to estimate cholesterol synthesis and absorption. The mean (+/- SD) time of the follow-up for all-cause and cardiovascular mortality was 7.32 (+/- 2.3) years. All-cause (P = 0.001) and cardiovascular (P = 0.006) mortality were decreased in the highest versus the lowest lathosterol to cholesterol tertile. In contrast, subjects in the third cholestanol to cholesterol tertile had increased all-cause (P < 0.001) and cardiovascular mortality (P = 0.010) compared with individuals in the first tertile. The third campesterol to cholesterol tertile was associated with increased all-cause mortality (P = 0.025). Sitosterol to cholesterol tertiles were not significantly related to all-cause or cardiovascular mortality. The data suggest that high absorption and low synthesis of cholesterol predict increased all-cause and cardiovascular mortality in LURIC participants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.