SynthesisAmerican journal of epidemiology2010
The association between atopy and childhood/adolescent leukemia: a meta-analysis.
Synthesis in American journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Allergies and Childhood Acute Lymphoblastic Leukemia: A Case-Control Study and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Pooled it
- Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta-analyses from the Childhood Leukemia International Consortium.Cancer medicine · 2018Pooled it
- Radiation exposure from computerized tomography and risk of childhood leukemia: Finnish register-based case-control study of childhood leukemia (FRECCLE).Haematologica · 2018Trial
- A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies.Clinical and translational allergy · 2026Review
- Review
- Does Asthma Affect the Risk of Developing Breast Cancer?Cancer medicine · 2025Article
- Skin Dialogues in Atopic Dermatitis.Diagnostics (Basel, Switzerland) · 2022Review
- Article
- Association of the presence of allergic disease with subsequent risk of liver cancer in a nationwide retrospective cohort among Koreans.Scientific reports · 2022Article
- AllergoOncology: Role of immune cells and immune proteins.Clinical and translational allergy · 2022Review
- Residential proximity to agriculture and risk of childhood leukemia and central nervous system tumors in the Danish national birth cohort.Environment international · 2020Article
- Early immune stimulation and childhood acute lymphoblastic leukemia in Costa Rica: A comparison of statistical approaches.Environmental research · 2020Article
- Acute myeloid leukemia with adult atopic dermatitis as first manifestation: A case report.Medicine · 2019Article
- Risks for comorbidity in children with atopic disorders: an observational study in Dutch general practices.BMJ open · 2017Observational
- Livestock and poultry density and childhood cancer incidence in nine states in the USA.Environmental research · 2017Article
- Trends in childhood leukemia incidence over two decades from 1992 to 2013.International journal of cancer · 2017Article
- Article
- Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma.Current dermatology reports · 2017Review
- Opportunities During Early Life for Cancer Prevention: Highlights From a Series of Virtual Meetings With Experts.Pediatrics · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Atopic disease is hypothesized to be protective against several malignancies, including childhood/adolescent leukemia. To summarize the available epidemiologic evidence, the authors performed a meta-analysis of associations between atopy/allergies, asthma, eczema, hay fever, and hives and childhood/adolescent leukemia, acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML). They searched MEDLINE literature (1952-March 2009) and queried international experts to identify eligible studies. Ten case-control studies were included. Summary odds ratios and 95% confidence intervals were computed via random-effects models. Odds ratios for atopy/allergies were 1.42 (95% confidence interval (CI): 0.60, 3.35) for 3 studies of leukemia overall, 0.69 (95% CI: 0.54, 0.89) for 6 studies of ALL, and 0.87 (95% CI: 0.62, 1.22) for 2 studies of AML, with high levels of heterogeneity detected for leukemia overall and ALL. Inverse associations were observed for ALL and asthma (odds ratio (OR) = 0.79, 95% CI: 0.61, 1.02), eczema (OR = 0.74, 95% CI: 0.58, 0.96), and hay fever (OR = 0.55, 95% CI: 0.46, 0.66) examined separately. Odds ratios for ALL differed by study design, exposure data source, and latency period, indicating that these factors affect study results. These results should be interpreted cautiously given the modest number of studies, substantial heterogeneity, and potential exposure misclassification but are useful in designing future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.