ArticleBiomaterials2010
Stimulation of in vivo angiogenesis by in situ crosslinked, dual growth factor-loaded, glycosaminoglycan hydrogels.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 83 citations in OpenAlex.
- Engineering a heparin-mimetic biomaterial to promote tissue vascularization.Communications biology · 2025Article
- Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice.Diabetologia · 2021Article
- Kidney regeneration approaches for translation.World journal of urology · 2020Review
- Microfluidic fabrication of microcarriers with sequential delivery of VEGF and BMP-2 for bone regeneration.Scientific reports · 2020Article
- The Combined Use of Negative-Pressure Wound Therapy and Dermal Substitutes for Tissue Repair and Regeneration.BioMed research international · 2020Review
- Biomaterials for In Situ Tissue Regeneration: A Review.Biomolecules · 2019Review
- Syntheses of defined sulfated oligohyaluronans reveal structural effects, diversity and thermodynamics of GAG-protein binding.Chemical science · 2019Article
- Thiol-Mediated Chemoselective Strategies forGels (Basel, Switzerland) · 2018Review
- A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery.Journal of biomedical materials research. Part B, Applied biomaterials · 2017Article
- Investigating thiol-modification on hyaluronan via carbodiimide chemistry using response surface methodology.Journal of biomedical materials research. Part A · 2015Article
- Effect of semisynthetic extracellular matrix-like hydrogel containing hepatocyte growth factor on repair of femoral neck defect in rabbits.International journal of clinical and experimental medicine · 2015Article
- Ophthalmic Uses of a Thiol-Modified Hyaluronan-Based Hydrogel.Advances in wound care · 2014Review
- Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications.Acta biomaterialia · 2014Review
- In situ tissue regeneration through host stem cell recruitment.Experimental & molecular medicine · 2013Review
- Specific VEGF sequestering to biomaterials: influence of serum stability.Acta biomaterialia · 2013Article
- Controlled release strategies for bone, cartilage, and osteochondral engineering--Part II: challenges on the evolution from single to multiple bioactive factor delivery.Tissue engineering. Part B, Reviews · 2013Review
- Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2.Biomaterials · 2012Article
- Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function.Biomaterials · 2012Article
- Hyaluronic acid-based clinical biomaterials derived for cell and molecule delivery in regenerative medicine.Journal of controlled release : official journal of the Controlled Release Society · 2011Review
- Hyaluronic acid hydrogels for biomedical applications.Advanced materials (Deerfield Beach, Fla.) · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
As part of a study of elicited angiogenesis, hyaluronan (HA)-based hydrogels crosslinked by polyethylene glycol diacrylate (PEGDA) were loaded with combinations of the cytokine growth factors vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), keratinocyte growth factor (KGF) and platelet-derived growth factor (PDGF). GF release in vivo was controlled by covalent incorporation of thiol-modified heparin into thiolated HA hydrogels, which were injected into the ear pinnae of mice and allowed to crosslink in situ. GF release in vivo was controlled by covalent incorporation of thiol-modified heparin in the gels. The ears were harvested at 7 or 14 days post-implantation, and vascularization evaluated via a Neovascularization Index (NI). The study demonstrates that in situ gelling implants produced no gross inflammation, redness or swelling, and an improved tolerance compared to HA-based dry film implants. All treatments showed significantly more vascularization than either contralateral ears or ears receiving a sham surgery. The maximum response was observed after 14 days in the ears receiving 0.3% Hp, gelatin-containing gels loaded with VEGF + KGF (NI = 3.91). The study revealed injected growth factor-loaded HA-based hydrogels can successfully produce localized controllable vascularization, while minimizing tissue necrosis, polymorphonuclear leukocytes and inflammation. The ability to target and controllably release growth factors can prove a useful tool in specific diseased tissue/organ angiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.