The HIV-1 Tat team gets bigger.

Andrew P Rice

Open access · bronzeAbstract readComment

In one paragraph

Article in Cell host & microbe, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact, top 90% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency.mBio · 2018
Article
Subcutaneous administration CpG-ODNs acts as a potent adjuvant for an HIV-1-tat-based vaccine candidate to elicit cellular immunity in BALB/c mice.Biotechnology letters · 2018
Article

4 · The record

Corrections and comments

Comment on
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription.2010

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Andrew P RiceDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. arice@bcm.edu

Baylor College of Medicine · US

Funding

Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015

$21.7M

Mechanisms of HIV-1 latency in CD4+ T lymphocytesR01AI035381 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 1995 to 2007

$2.5M

Identification of novel HIV-1 co-factorsR21AI080222 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 2009 to 2010

$420k

Mechanism of HIV-1 Tat FunctionR56AI035381 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 2009 to 2009

$384k

NIAID NIH HHS AI35381NIAID NIH HHS AI80222NIAID NIH HHS P30 AI036211

6 · The paper itself

Abstract

Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.

Identifiers

PMID20227660

DOI10.1016/j.chom.2010.03.001

OpenAlexW2058577575

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.