ReviewThe international journal of biochemistry & cell biology2010
Small RNAs in the animal gonad: guarding genomes and guiding development.
Review in The international journal of biochemistry & cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- miR-458b-5p regulates ovarian granulosa cells proliferation through Wnt/β-catenin signaling pathway by targeting catenin beta-1.Animal bioscience · 2021Article
- Review
- Histone Post-Translational Modifications and CircRNAs in Mouse and Human Spermatozoa: Potential Epigenetic Marks to Assess Human Sperm Quality.Journal of clinical medicine · 2020Review
- Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors.Human gene therapy methods · 2017Review
- Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals.PLoS genetics · 2015Article
- Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon.G3 (Bethesda, Md.) · 2015Article
- Transposable element dynamics and PIWI regulation impacts lncRNA and gene expression diversity in Drosophila ovarian cell cultures.Genome research · 2014Article
- Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape.Nature structural & molecular biology · 2014Article
- Article
- Piwi Proteins and piRNAs step onto the systems biology stage.Advances in experimental medicine and biology · 2014Article
- Article
- Article
- Untangling the web: the diverse functions of the PIWI/piRNA pathway.Molecular reproduction and development · 2013Review
- Promoters recognized by forkhead proteins exist for individual 21U-RNAs.Molecular cell · 2012Article
- Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast.The EMBO journal · 2012Article
- Aphids: a model for polyphenism and epigenetics.Genetics research international · 2012Article
- Article
- Deciphering arginine methylation: Tudor tells the tale.Nature reviews. Molecular cell biology · 2011Review
- A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.PLoS genetics · 2011Article
- Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Germ cells must safeguard, apportion, package, and deliver their genomes with exquisite precision to ensure proper reproduction and embryonic development. Classical genetic approaches have identified many genes controlling animal germ cell development, but only recently have some of these genes been linked to the RNA interference (RNAi) pathway, a gene silencing mechanism centered on small regulatory RNAs. Germ cells contain microRNAs (miRNAs), endogenous siRNAs (endo-siRNAs), and Piwi-interacting RNAs (piRNAs); these are bound by members of the Piwi/Argonaute protein family. piwi genes were known to specify germ cell development, but we now understand that mutations disrupting germline development can also affect small RNA accumulation. Small RNA studies in germ cells have revealed a surprising diversity of regulatory mechanisms and a unifying function for germline genes in controlling the spread of transposable elements. Future challenges will be to understand the production of germline small RNAs and to identify the full breadth of gene regulation by these RNAs. Progress in this area will likely impact biomedical goals of manipulating stem cells and preventing diseases caused by the transposition of mobile DNA elements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.