ArticleEpilepsy & behavior : E&B2010
Seizure control in patients with idiopathic generalized epilepsies: EEG determinants of medication response.
Article in Epilepsy & behavior : E&B, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Trial
- Article
- Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis.EClinicalMedicine · 2022Article
- Risk factors for Drug-resistant Epilepsy (DRE) and a nomogram model to predict DRE development in post-traumatic epilepsy patients.CNS neuroscience & therapeutics · 2022Article
- EEG Markers of Treatment Resistance in Idiopathic Generalized Epilepsy: From Standard EEG Findings to Advanced Signal Analysis.Biomedicines · 2022Review
- Clinical and Instrumental Follow-Up of Childhood Absence Epilepsy (CAE): Exploration of Prognostic Factors.Children (Basel, Switzerland) · 2022Article
- Seizure frequency discrepancy between subjective and objective ictal electroencephalography data in dogs.Journal of veterinary internal medicine · 2021Article
- Recent Advances in Neuroimaging of Epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Clinical Management of Drug Resistant Epilepsy: A Review on Current Strategies.Neuropsychiatric disease and treatment · 2021Review
- Development and validation of a predictive model of drug-resistant genetic generalized epilepsy.Neurology · 2020Observational
- Genetic generalized and focal epilepsy prevalence in the North American SUDEP Registry.Neurology · 2020Article
- EEG correlates of seizure freedom in genetic generalized epilepsies.Neurology. Clinical practice · 2017Article
- High-dose versus low-dose valproate for the treatment of juvenile myoclonic epilepsy: Going from low to high.Epilepsy & behavior : E&B · 2016Article
- Focal interictal epileptiform discharges in idiopathic generalized epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- White Matter Abnormalities in Patients with Treatment-Resistant Genetic Generalized Epilepsies.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Methods and utility of EEG-fMRI in epilepsy.Quantitative imaging in medicine and surgery · 2015Review
- EEG/fMRI contributions to our understanding of genetic generalized epilepsies.Epilepsy & behavior : E&B · 2014Review
- Prognostic value of EEG asymmetries for development of drug-resistance in drug-naïve patients with genetic generalized epilepsies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2014Article
- Differences in paracingulate connectivity associated with epileptiform discharges and uncontrolled seizures in genetic generalized epilepsy.Epilepsia · 2014Article
- Insights into the mechanisms of absence seizure generation provided by EEG with functional MRI.Frontiers in neurology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In a minority of patients with idiopathic generalized epilepsies (IGEs), seizures continue despite appropriate treatment. We sought to determine the clinical and EEG factors associated with medication response in these patients. All patients with IGEs evaluated by epilepsy specialists between 17 November 2008 and 16 November 2009 were included. We collected information on seizure freedom (dependent variable), EEG asymmetries, response to valproic acid (VPA), MRI characteristics, medication use, demographics, and seizure history (predictors). We identified 322 patients with IGEs; 45 (14%) were excluded from analyses because they had always had a normal EEG (N=26), there were no EEG data (N=3), or they were non-compliant with medication (N=26). Patients with juvenile myoclonic epilepsy were more likely to respond to VPA than were patients with other IGEs, and VPA response was associated with seizure freedom. When EEG characteristics were considered, presence of any focal EEG abnormalities (focal slowing, focal epileptiform discharges, or both) was associated with decreased odds of seizure freedom. These findings suggest that patients with IGEs with poor seizure control may have atypical IGEs with possibly focal, for example, frontal, rather than thalamic onset.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.