Trial reportAmerican journal of obstetrics and gynecology2010
Respiratory compliance in preterm infants after a single rescue course of antenatal steroids: a randomized controlled trial.
Trial report in American journal of obstetrics and gynecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00669383 (Rescue Antenatal Steroids and Lung Volumes in Preterm Infants), which is not on this map. Cited by 38 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rescue Antenatal Steroids and Lung Volumes in Preterm Infants
Who cites it
38 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- The proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes: systematic review and meta-analysis of 1.6 million infants.BMJ (Clinical research ed.) · 2023Pooled it
- Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes.The Cochrane database of systematic reviews · 2022Pooled it
- Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis.PLoS medicine · 2019Pooled it
- Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.The Cochrane database of systematic reviews · 2017Pooled it
- Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes.The Cochrane database of systematic reviews · 2015Pooled it
- Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes.The Cochrane database of systematic reviews · 2011Pooled it
- The Effect of Extended Continuous Positive Airway Pressure on Changes in Lung Volumes in Stable Premature Infants: A Randomized Controlled Trial.The Journal of pediatrics · 2020Trial
- The window of improved neonatal respiratory compliance after rescue antenatal steroids.Journal of perinatology : official journal of the California Perinatal Association · 2018Trial
- Pulmonary function and outcomes in infants randomized to a rescue course of antenatal steroids.Pediatric pulmonology · 2017Trial
- Pulmonary Function at Hospital Discharge in Preterm Infants Randomized to a Single Rescue Course of Antenatal Steroids.The Journal of pediatrics · 2017Trial
- Antenatal corticosteroids for preterm premature rupture of membranes: single or repeat course?American journal of perinatology · 2015Trial
- Trial
- Pulmonary function tests in the neonatal intensive care unit and beyond: a clinical review.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Presurgical pulmonary function tests in the first few days of life in neonates with congenital heart disease, a pilot study.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Late preterm antenatal steroid use and infant outcomes in a single center.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Comparison of High-Frequency Oscillatory Ventilators.Respiratory care · 2024Article
- Late Preterm Antenatal Steroid Use and Infant Outcomes in a Single Center.Research square · 2023Article
- Antenatal Steroids and Cord Blood T-cell Glucocorticoid Receptor DNA Methylation and Exon 1 Splicing.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Comparison of respiratory distress syndrome amongst preterm twins (28-34 Weeks) born within and after two weeks of completion of single antenatal corticosteroid course: A bidirectional cohort study.Journal of mother and child · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveTo compare respiratory compliance and functional residual capacity in infants randomized to a rescue course of antenatal steroids vs placebo. STUDY
designRandomized, double-blinded trial. Pregnant women > or =14 days after initial antenatal steroids were randomized to rescue antenatal steroids or placebo. The primary outcomes were measurements of respiratory compliance and functional residual capacity. This study is registered with clinicaltrials.gov (NCT00669383).
resultsForty-four mothers (56 infants) received rescue antenatal steroids and 41 mothers (57 infants) received placebo. There was no significant difference in birthweight, or head circumference. Infants in the rescue group had an increased respiratory compliance (1.21 vs 1.01 mL/cm H(2)O/kg; adjusted 95% confidence interval, 0.01-0.49; P = .0433) compared with placebo. 13% in the rescue vs 29% in the placebo group required > or =30% oxygen (P < .05). Patients delivered at < or =34 weeks had greater pulmonary benefits.
conclusionInfants randomized to rescue antenatal steroids have a significantly increased respiratory compliance compared with placebo.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.