ArticleNeuroImage2010
The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models.
Article in NeuroImage, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Neurofilaments: neurobiological foundations for biomarker applications.Brain : a journal of neurology · 2020Review
- Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors.Translational psychiatry · 2018Article
- Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology.BMC neuroscience · 2018Article
- Postmortem MRI: a novel window into the neurobiology of late life cognitive decline.Neurobiology of aging · 2016Article
- Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders.Brain research bulletin · 2016Review
- Novel pathologic findings in patients with Pelizaeus-Merzbacher disease.Neuroscience letters · 2016Article
- Reprint of "Quantitative evaluation of brain development using anatomical MRI and diffusion tensor imaging".International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Article
- Quantitative evaluation of brain development using anatomical MRI and diffusion tensor imaging.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Review
- In vivo assessment of neurodegeneration in Niemann-Pick type C mice by quantitative T2 mapping and diffusion tensor imaging.Journal of magnetic resonance imaging : JMRI · 2012Article
- Human brain iron mapping using atlas-based T2 relaxometry.Magnetic resonance in medicine · 2012Article
- MRI characterization of paranodal junction failure and related spinal cord changes in mice.PloS one · 2012Article
- Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly sample.Journal of clinical and experimental neuropsychology · 2011Article
- Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
White matter disorders can involve injury to myelin or axons but the respective contribution of each to clinical course is difficult to evaluate non-invasively. Here, to develop a paradigm for further investigations of axonal pathology by MRI, we compared two genetic mouse models exhibiting relatively selective axonal or myelin deficits using quantitative MRI relaxography of the transverse relaxation times (T2) in vivo and ultrastructural morphometry. In HM-DKO mice, which lack genes encoding the heavy (NF-H) and medium (NF-M) subunits of neurofilaments, neurofilament content of large myelinated axons of the central nervous system (CNS) is markedly reduced in the absence of changes in myelin thickness and volume. In shiverer mutant mice, which lack functional myelin basic protein, CNS myelin sheath formation is markedly reduced but neurofilament content is normal. We observed increases in T2 in nearly all white matter in shiverer mice compared to their wild type, while more subtle increases in T2 were observed in HM-DKO in the corpus callosum. White matter T2 was generally greater in shiverer mice than HM-DKO mice. Ultrastructural morphometry of the corpus callosum, which exhibited the greatest T2 differences, confirmed that total cross-sectional area occupied by axons was similar in the two mouse models and that the major ultrastructural differences, determined by morphometry, were an absence of myelin and larger unmyelinated axons in shiverer mice and absence of neurofilaments in HM-DKO mice. Our findings indicate that T2 is strongly influenced by myelination state and axonal volume, while neurofilament structure within the intra-axonal compartment has a lesser effect upon single compartment T2 estimates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.