ArticleCurrent biology : CB2010
p53 prevents entry into mitosis with uncapped telomeres.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
- Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling.Biomarker research · 2024Article
- Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder.World journal of surgical oncology · 2023Article
- p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways.Cell death and differentiation · 2022Review
- cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence.Protein & cell · 2022Article
- The Connection Between Cell Fate and Telomere.Advances in experimental medicine and biology · 2021Review
- Telomerase and telomeres in aging theory and chronographic aging theory (Review).Molecular medicine reports · 2020Review
- Telomere length and telomerase activity in osteoporosis and osteoarthritis.Experimental and therapeutic medicine · 2020Review
- Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives.Molecular medicine reports · 2019Article
- Complex structural rearrangements are present in high-grade dysplastic Barrett's oesophagus samples.BMC medical genomics · 2019Article
- In aged primary T cells, mitochondrial stress contributes to telomere attrition measured by a novel imaging flow cytometry assay.Aging cell · 2017Article
- Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.Molecular and cellular biology · 2017Article
- The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response.Nucleic acids research · 2017Article
- Article
- TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.Molecular cell · 2016Article
- Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage.EMBO molecular medicine · 2015Article
- BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.The EMBO journal · 2015Article
- Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.Nature communications · 2014Article
- DNA damage to a single chromosome end delays anaphase onset.The Journal of biological chemistry · 2014Article
- Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status.Cancer biology & therapy · 2014Article
- γH2AX foci on apparently intact mitotic chromosomes: not signatures of misrejoining events but signals of unresolved DNA damage.Cell cycle (Georgetown, Tex.) · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Telomeres are protected by capping structures consisting of core protein complexes that bind with sequence specificity to telomeric DNA. In their absence, telomeres trigger a DNA damage response, materialized in accumulation at the telomere of damage response proteins, e.g., phosphorylated histone H2AX (gammaH2AX), into telomere-dysfunction-induced foci. Telomere uncapping occurs transiently in every cell cycle in G2, following DNA replication, but little is known about how protective structures are reassembled or whether this process is controlled by the cell-cycle surveillance machinery. Here, we report that telomere capping is monitored at the G2/M transition by the p53/p21 damage response pathway. Unlike their wild-type counterparts, human and mouse cells lacking p53 or p21 progress into mitosis prematurely with persisting uncapped telomeres. Furthermore, artificially uncapped telomeres delay mitotic entry in a p53- and p21-dependent manner. Uncapped telomeres that persist in mitotic p53-deficient cells are shorter than average and religate to generate end-to-end fusions. These results suggest that a p53-dependent pathway monitors telomere capping after DNA replication and delays G2/M progression in the presence of unprotected telomeres. This mechanism maintains a cell-cycle stage conducive for capping reactions and prevents progression into stages during which uncapped telomeres are prone to deleterious end fusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.