ArticleBiomaterials2010
Critical role of tissue mast cells in controlling long-term glucose sensor function in vivo.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- The regulatory role of immune microenvironment-related cells and pathways in the pathogenesis of keloids.Frontiers in immunology · 2025Review
- Impact of Bindarit, a CCL2 Chemokine Synthesis Inhibitor, on Macrophage-Based Biofouling and Continuous Glucose MonitoringBiosensors & bioelectronics: X · 2024Article
- Mast Cell Deficiency in Mice Attenuates Insulin Phenolic Preservative-Induced Inflammation.Biomedicines · 2023Article
- The intensity of the foreign body response to polyether-polyurethane implant in diabetic mice is strain-dependent.International journal of experimental pathology · 2021Article
- Advancing continuous subcutaneous insulin infusion in vivo: New insights into tissue challenges.Journal of biomedical materials research. Part A · 2021Article
- Phenolic Preservative Removal from Commercial Insulin Formulations Reduces Tissue Inflammation while Maintaining Euglycemia.ACS pharmacology & translational science · 2021Article
- Continuous Glucose Monitoring Devices: Past, Present, and Future Focus on the History and Evolution of Technological Innovation.Journal of diabetes science and technology · 2021Review
- Sodium Butyrate Downregulates Implant-Induced Inflammation in Mice.Inflammation · 2020Article
- Carcinogenesis: the cancer cell-mast cell connection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer.Nature biomedical engineering · 2018Article
- In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility.Analytical chemistry · 2017Review
- Impact of CCL2 and CCR2 chemokine/receptor deficiencies on macrophage recruitment and continuous glucose monitoring in vivo.Biosensors & bioelectronics · 2016Article
- Fully Implantable Arterial Blood Glucose Device for Metabolic Research Applications in Rats for Two Months.Journal of diabetes science and technology · 2015Article
- Role of vascular networks in extending glucose sensor function: Impact of angiogenesis and lymphangiogenesis on continuous glucose monitoring in vivo.Journal of biomedical materials research. Part A · 2014Article
- Interstitium versus Blood Equilibrium in Glucose Concentration and its Impact on Subcutaneous Continuous Glucose Monitoring Systems.European endocrinology · 2014Article
- Role of interleukin-1/interleukin-1 receptor antagonist family of cytokines in long-term continuous glucose monitoring in vivo.Journal of diabetes science and technology · 2013Article
- Continuous glucose monitoring: current use and future directions.Current diabetes reports · 2013Review
- Biocompatible materials for continuous glucose monitoring devices.Chemical reviews · 2013Review
- Analysis: on the path to overcoming glucose-sensor-induced foreign body reactions.Journal of diabetes science and technology · 2013Article
- The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants.Biomaterials · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Little is known about the specific cells, mediators and mechanisms involved in the loss of glucose sensor function (GSF) in vivo. Since mast cells (MC) are known to be key effector cells in inflammation and wound healing, we hypothesized that MC and their products are major contributors to the skin inflammation and wound healing that controls GSF at sites of sensor implantation. To test this hypothesis we utilized a murine model of continuous glucose monitoring (CGM) in vivo in both normal C57BL/6 mice (mast cell sufficient), as well as mast cell deficient B6.Cg-Kit(W-sh)/HNihrJaeBsmJ (Sash) mice over a 28 day CGM period. As expected, both strains of mice displayed excellent CGM for the first 7 days post sensor implantation (PSI). CGM in the mast cell sufficient C57BL/6 mice was erratic over the remaining 21 days PSI. CGM in the mast cell deficient Sash mice displayed excellent sensor function for the entire 28 day of CGM. Histopathologic evaluation of implantation sites demonstrated that tissue reactions in Sash mice were dramatically less compared to the reactions in normal C57BL/6 mice. Additionally, mast cells were also seen to be consistently associated with the margins of sensor tissue reactions in normal C57BL/6 mice. Finally, direct injection of bone marrow derived mast cells at sites of sensor implantation induced an acute and dramatic loss of sensor function in both C57BL/6 and Sash mice. These results demonstrate the key role of mast cells in controlling glucose sensor function in vivo.
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