ArticleThe Journal of allergy and clinical immunology2010
Asthma control, adiposity, and adipokines among inner-city adolescents.
Article in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it, 176 citations in OpenAlex.
- Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma.Pediatrics · 2014Pooled it
- Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents.The Journal of allergy and clinical immunology · 2016Trial
- Obesity and adiposity indicators, asthma, and atopy in Puerto Rican children.The Journal of allergy and clinical immunology · 2014Trial
- Impact of weight loss on markers of systemic inflammation in obese Saudi children with asthma.African health sciences · 2013Trial
- Obesity in children with poorly controlled asthma: Sex differences.Pediatric pulmonology · 2013Trial
- Body mass index is a stronger predictor than the metabolic syndrome for future asthma in women. The longitudinal CARDIA study.American journal of respiratory and critical care medicine · 2013Trial
- Cluster analysis of obesity and asthma phenotypes.PloS one · 2012Trial
- Associations between body weight, asthma burden, and type 2 inflammation among under-resourced children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Are single-nucleotide polymorphisms previously linked to inhaled corticosteroid response associated with obese-asthma in children?Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Association of Obesity and Severe Asthma in Adults.Journal of clinical medicine · 2024Review
- Circulating levels of adiponectin and AdipoR expression in peripheral blood mononuclear cells are associated with lower respiratory tract Infection.Frontiers in immunology · 2024Article
- Time-Specific Factors Influencing the Development of Asthma in Children.Biomedicines · 2022Review
- Perimenstrual Asthma in Adolescents: A Shared Condition in Pediatric and Gynecological Endocrinology.Children (Basel, Switzerland) · 2022Review
- Regulatory Peptides in Asthma.International journal of molecular sciences · 2021Review
- Trajectories of adiposity indicators and association with asthma and lung function in urban minority children.The Journal of allergy and clinical immunology · 2021Article
- Review
- Asthma and Obesity: Two Diseases on the Rise and Bridged by Inflammation.Journal of clinical medicine · 2021Review
- Atopy and pulmonary function among healthy-weight and overweight/obese children with asthma.Pediatric pulmonology · 2021Article
- Wheezing-Related Relevant Factors and the Role of Viral Bronchiolitis.Frontiers in allergy · 2021Review
- Recent Insights into the Management of Inflammation in Asthma.Journal of inflammation research · 2021Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundThere is an association between adiposity and asthma prevalence, but the relationship to asthma control is unclear.
objectivesWe sought to understand the relationships among adiposity, sex, and asthma control in inner-city adolescents with asthma.
methodsWe prospectively followed 368 adolescents with moderate-to-severe asthma (ages 12-20 years) living in 10 urban areas for 1 year. Asthma symptoms and exacerbations were recorded, and pulmonary function and exhaled nitric oxide levels were measured every 6 weeks. Adiposity measures (body mass index [BMI] and dual-energy X-ray absorptiometric scans) were made, and blood was collected for measurement of allergy markers, adiponectin, leptin, TNF-alpha, IL-6, and C-reactive protein levels.
resultsMore than 60% of female subjects and 50% of male subjects were above the 85th percentile of BMI for age. Higher BMI was associated with more symptom days (R = 0.18, P = .02) and exacerbations (R = 0.18, P = .06) among female subjects only. Adiponectin was inversely related to asthma symptoms (R = -0.18, P < .05) and exacerbations (R = -0.20, P < .05) and positively with FEV(1)/forced vital capacity ratio (R = 0.15, P < .05) in male subjects only independent of body size. There was no relationship between adiposity or adipokines and total IgE levels, blood eosinophil counts, and exhaled nitric oxide levels. Dual-energy X-ray absorptiometry provided little additional value in relating adiposity to asthma outcome in this population of adolescents.
conclusionAdiposity is associated with poorer asthma control in female subjects. Adiponectin is associated with improved asthma control in male subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.