ArticleBiochemical and biophysical research communications2010
Inward-rectifier chloride currents in Reissner's membrane epithelial cells.
Article in Biochemical and biophysical research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Pilot Study of Audiometric Patterns in Fuchs Corneal Dystrophy.Journal of speech, language, and hearing research : JSLHR · 2018Article
- Slc26a7 chloride channel activity and localization in mouse Reissner's membrane epithelium.PloS one · 2014Article
- Human fetal inner ear involvement in congenital cytomegalovirus infection.Acta neuropathologica communications · 2013Article
- Regulation of sodium transport in the inner ear.Hearing research · 2011Review
- Sodium selectivity of Reissner's membrane epithelial cells.BMC physiology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sensory transduction in the cochlea depends on regulated ion secretion and absorption. Results of whole-organ experiments suggested that Reissner's membrane may play a role in the control of luminal Cl(-). We tested for the presence of Cl(-) transport pathways in isolated mouse Reissner's membrane using whole-cell patch clamp recording and gene transcript analyses using RT-PCR. The current-voltage (I-V) relationship in the presence of symmetrical NMDG-Cl was strongly inward-rectifying at negative voltages, with a small outward current at positive voltages. The inward-rectifying component of the I-V curve had several properties similar to those of the ClC-2 Cl(-) channel. It was stimulated by extracellular acidity and inhibited by extracellular Cd2+, Zn2+ and intracellular ClC-2 antibody. Channel transcripts expressed include ClC-2, Slc26a7 and ClC-Ka, but not Cftr, ClC-1, ClCa1, ClCa2, ClCa3, ClCa4, Slc26a9, ClC-Kb, Best1, Best2, Best3 or the beta-subunit of ClC-K, barttin. ClC-2 is the only molecularly-identified channel present that is a strong inward rectifier. This study is the first report of conductive Cl(-) transport in epithelial cells of Reissner's membrane and is consistent with an important role in endolymph anion homeostasis.
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