ArticleParticle and fibre toxicology2010
Inflammogenic effect of well-characterized fullerenes in inhalation and intratracheal instillation studies.
Article in Particle and fibre toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 77 citations in OpenAlex.
- Article
- Comparison of lung disorders following intratracheal instillation of polystyrene microplastics with different surface functional groups.Journal of occupational health · 2025Article
- Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration.Archives of toxicology · 2024Article
- Investigation of pulmonary inflammatory responses following intratracheal instillation of and inhalation exposure to polypropylene microplastics.Particle and fibre toxicology · 2024Article
- Assessment of Cytokine-Induced Neutrophil Chemoattractants as Biomarkers for Prediction of Pulmonary Toxicity of Nanomaterials.Nanomaterials (Basel, Switzerland) · 2020Article
- Effects of administering different vehicles via single intratracheal instillation on responses in the lung and pleural cavity of Crl:CD(SD) rats.Journal of toxicologic pathology · 2020Article
- Long-term observation of pulmonary toxicity of toner with external additives following a single intratracheal instillation in rats.Journal of occupational health · 2020Article
- Mechanistic Understanding of Cell Recognition and Immune Reaction via CR1/CR3 by HAP- and SiOBioMed research international · 2020Article
- Toxicity of Zero- and One-Dimensional Carbon Nanomaterials.Nanomaterials (Basel, Switzerland) · 2019Review
- Assessment of Pulmonary Toxicity Induced by Inhaled Toner with External Additives.BioMed research international · 2017Article
- Article
- Evaluation of Pulmonary Toxicity of Zinc Oxide Nanoparticles Following Inhalation and Intratracheal Instillation.International journal of molecular sciences · 2016Article
- Usefulness of Intratracheal Instillation Studies for Estimating Nanoparticle-Induced Pulmonary Toxicity.International journal of molecular sciences · 2016Review
- Exposure to nickel oxide nanoparticles induces pulmonary inflammation through NLRP3 inflammasome activation in rats.International journal of nanomedicine · 2016Article
- C₆₀ exposure augments cardiac ischemia/reperfusion injury and coronary artery contraction in Sprague Dawley rats.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation.Particle and fibre toxicology · 2014Article
- Significance of persistent inflammation in respiratory disorders induced by nanoparticles.Journal of immunology research · 2014Review
- Beyond nC60: strategies for identification of transformation products of fullerene oxidation in aquatic and biological samples.Analytical and bioanalytical chemistry · 2012Review
- Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model.Particle and fibre toxicology · 2011Article
- Pulmonary toxicity of well-dispersed titanium dioxide nanoparticles following intratracheal instillation.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technologyArticle
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe used fullerenes, whose dispersion at the nano-level was stabilized by grinding in nitrogen gas in an agitation mill, to conduct an intratracheal instillation study and an inhalation exposure study. Fullerenes were individually dispersed in distilled water including 0.1% Tween 80, and the diameter of the fullerenes was 33 nm. These suspensions were directly injected as a solution in the intratracheal instillation study. The reference material was nickel oxide in distilled water. Wistar male rats intratracheally received a dose of 0.1 mg, 0.2 mg, or 1 mg of fullerenes and were sacrificed after 3 days, 1 week, 1 month, 3 months, and 6 months. In the inhalation study, Wistar rats were exposed to fullerene agglomerates (diameter: 96 +/- 5 nm; 0.12 +/- 0.03 mg/m3; 6 hours/days for 5 days/week) for 4 weeks and were sacrificed at 3 days, 1 month, and 3 months after the end of exposure. The inflammatory responses and gene expression of cytokine-induced neutrophil chemoattractants (CINCs) were examined in rat lungs in both studies.
resultsIn the intratracheal instillation study, both the 0.1 mg and 0.2 mg fullerene groups did not show a significant increase of the total cell and neutrophil count in BALF or in the expression of CINC-1,-2alphabeta and-3 in the lung, while the high-dose, 1 mg group only showed a transient significant increase of neutrophils and expression of CINC-1,-2alphabeta and -3. In the inhalation study, there were no increases of total cell and neutrophil count in BALF, CINC-1,-2alphabeta and-3 in the fullerene group.
conclusionThese data in intratracheal instillation and inhalation studies suggested that well-dispersed fullerenes do not have strong potential of neutrophil inflammation.
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