ArticleSilence2010
Expression patterns of intronic microRNAs in Caenorhabditis elegans.
Article in Silence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 70 citations in OpenAlex.
- Characterization, functional exploration, and evolutionary analysis of mirtronic microRNAs reveal their origin in the invasive vector mosquito, Aedes albopictus.Insect science · 2026Article
- MicroRNAs' Impact on Heart Diseases.International journal of molecular sciences · 2025Review
- Novel C. elegans models of Lewy body disease reveal pathological protein interactions and widespread miRNA dysregulation.Cellular and molecular life sciences : CMLS · 2024Article
- A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis.Nature communications · 2024Article
- Transcription of microRNAs is regulated by developmental signaling pathways and transcription factors.Frontiers in cell and developmental biology · 2024Article
- MicroRNAs' Role in Diagnosis and Treatment of Subarachnoid Hemorrhage.Diseases (Basel, Switzerland) · 2023Review
- The Importance of MicroRNA Expression in Pseudoexfoliation Syndrome.International journal of molecular sciences · 2022Review
- microRNAs in Subarachnoid Hemorrhage (Review of Literature).Journal of clinical medicine · 2022Review
- MicroRNA-Based Diagnosis and Therapy.International journal of molecular sciences · 2022Review
- Role of circRNA-miRNA-mRNA interaction network in diabetes and its associated complications.Molecular therapy. Nucleic acids · 2021Review
- Composition of Caenorhabditis elegans extracellular vesicles suggests roles in metabolism, immunity, and aging.GeroScience · 2020Article
- Role of cardiac progenitor cell-derived exosome-mediated microRNA-210 in cardiovascular disease.Journal of cellular and molecular medicine · 2019Review
- MicroRNAs - novel biomarkers for malignant pleural effusions.Contemporary oncology (Poznan, Poland) · 2019Review
- A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targetingClinical epigenetics · 2018Article
- Dysregulation of both miR-140-3p and miR-140-5p in synovial fluid correlate with osteoarthritis severity.Bone & joint research · 2017Article
- miRNAs as Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer: Current Perspectives.Targeted oncology · 2017Review
- miRNAs cooperate in apoptosis regulation duringGenes & development · 2017Article
- Comparative genomic analysis of upstream miRNA regulatory motifs in Caenorhabditis.RNA (New York, N.Y.) · 2016Article
- Article
- miR-58 family and TGF-β pathways regulate each other in Caenorhabditis elegans.Nucleic acids research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNA) are an abundant and ubiquitous class of small RNAs that play prominent roles in gene regulation. A significant fraction of miRNA genes reside in the introns of the host genes in the same orientation and are thought to be co-processed from the host gene mRNAs and thus depend on the host gene promoter for their expression. However, several lines of evidence for independent expression of intronic miRNAs exist in the literature but the extent of this independence remains unclear.
resultsWe performed a systematic analysis of genomic regions surrounding intronic miRNAs in the nematode Caenorhabditis elegans and found that, in many cases, there are extended intronic sequences immediately upstream of the miRNAs that are well-conserved between the nematodes. We have generated transcriptional green fluorescent protein reporter fusions in transgenic C. elegans lines and demonstrated that, in all seven investigated cases, the conserved sequences show promoter properties and produce specific expression patterns that are different from the host gene expression patterns. The observed expression patterns are corroborated by the published small RNA sequencing data.
conclusionsOur analysis reveals that the number of intronic miRNAs that do not rely on their host genes for expression is substantially higher than previously appreciated. At least one-third of the same-strand intronic miRNAs in C. elegans posses their own promoters and, thus, could be transcribed independently from their host genes. These findings provide a new insight into the regulation of miRNA genes and will be useful for the analysis of interactions between miRNAs and their host genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.