ArticleBMC genomics2010
Whole genome evaluation of horizontal transfers in the pathogenic fungus Aspergillus fumigatus.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Horizontal Gene Transfer Involving Chloroplasts.International journal of molecular sciences · 2021Review
- Horizontal Gene Transfer and Endophytes: An Implication for the Acquisition of Novel Traits.Plants (Basel, Switzerland) · 2020Review
- The Genome of the Fungal Pathogen Verticillium dahliae Reveals Extensive Bacterial to Fungal Gene Transfer.Genome biology and evolution · 2019Article
- EuGI: a novel resource for studying genomic islands to facilitate horizontal gene transfer detection in eukaryotes.BMC genomics · 2018 · on this mapArticle
- MTGIpick allows robust identification of genomic islands from a single genome.Briefings in bioinformatics · 2018Article
- Genomic Data Quality Impacts Automated Detection of Lateral Gene Transfer in Fungi.G3 (Bethesda, Md.) · 2017Article
- Globally distributed root endophyte Phialocephala subalpina links pathogenic and saprophytic lifestyles.BMC genomics · 2016Article
- Horizontally acquired genes in early-diverging pathogenic fungi enable the use of host nucleosides and nucleotides.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- HGT-Finder: A New Tool for Horizontal Gene Transfer Finding and Application to Aspergillus genomes.Toxins · 2015Article
- Lateral gene transfers and the origins of the eukaryote proteome: a view from microbial parasites.Current opinion in microbiology · 2015Review
- Horizontal gene transfer in plants.Functional & integrative genomics · 2014Review
- The function and evolution of the Aspergillus genome.Trends in microbiology · 2013Review
- GOHTAM: a website for 'Genomic Origin of Horizontal Transfers, Alignment and Metagenomics'.Bioinformatics (Oxford, England) · 2012Article
- CysQ of Cryptosporidium parvum, a Protozoa, May Have Been Acquired from Bacteria by Horizontal Gene Transfer.Genomics & informatics · 2012Article
- Large-scale introgression shapes the evolution of the mating-type chromosomes of the filamentous ascomycete Neurospora tetrasperma.PLoS genetics · 2012Article
- Interkingdom gene transfer may contribute to the evolution of phytopathogenicity in botrytis cinerea.Evolutionary bioinformatics online · 2012Article
- Bacterial-fungal interactions: hyphens between agricultural, clinical, environmental, and food microbiologists.Microbiology and molecular biology reviews : MMBR · 2011Review
- Phylogenetic and functional analysis of Aspergillus fumigatus MGTC, a fungal protein homologous to a bacterial virulence factor.Applied and environmental microbiology · 2011Article
- Horizontal gene transfers with or without cell fusions in all categories of the living matter.Advances in experimental medicine and biology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous cases of horizontal transfers (HTs) have been described for eukaryote genomes, but in contrast to prokaryote genomes, no whole genome evaluation of HTs has been carried out. This is mainly due to a lack of parametric methods specially designed to take the intrinsic heterogeneity of eukaryote genomes into account. We applied a simple and tested method based on local variations of genomic signatures to analyze the genome of the pathogenic fungus Aspergillus fumigatus.
resultsWe detected 189 atypical regions containing 214 genes, accounting for about 1 Mb of DNA sequences. However, the fraction of atypical DNA detected was smaller than the average amount detected in the same conditions in prokaryote genomes (3.1% vs 5.6%). It appeared that about one third of these regions contained no annotated genes, a proportion far greater than in prokaryote genomes. When analyzing the origin of these HTs by comparing their signatures to a home made database of species signatures, 3 groups of donor species emerged: bacteria (40%), fungi (25%), and viruses (22%). It is to be noticed that though inter-domain exchanges are confirmed, we only put in evidence very few exchanges between eukaryotic kingdoms.
conclusionsIn conclusion, we demonstrated that HTs are not negligible in eukaryote genomes, bearing in mind that in our stringent conditions this amount is a floor value, though of a lesser extent than in prokaryote genomes. The biological mechanisms underlying those transfers remain to be elucidated as well as the biological functions of the transferred genes.
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