ArticleBMC physiology2010
High-resolution ex vivo magnetic resonance angiography: a feasibility study on biological and medical tissues.
Article in BMC physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Anatomical digital twins for medical education: a stepwise guide to create perpetual multimodal three-dimensional reconstruction of digital brain specimens.Quantitative imaging in medicine and surgery · 2025Article
- Fetal-placental MR angiography at 1.5 T and 3 T.Magnetic resonance imaging · 2023Article
- Do air-breathing fish suffer branchial oxygen loss in hypoxic water?Proceedings. Biological sciences · 2023Article
- Magnetic Resonance Imaging Angiography of Physiological and Pathological Pregnancy Placentas Ex Vivo: Protocol for a Prospective Pilot Study.JMIR research protocols · 2022Article
- Underwater photogrammetry for close-range 3D imaging of dry-sensitive objects: The case study of cephalopod beaks.Ecology and evolution · 2021Article
- Article
- Ex Vivo Human Placenta Perfusion, Metabolic and Functional Imaging for Obstetric Research-A Feasibility Study.Tomography (Ann Arbor, Mich.) · 2019Article
- Placental MRI: Developing Accurate Quantitative Measures of Oxygenation.Topics in magnetic resonance imaging : TMRI · 2019Review
- The chinchilla as a novel animal model of pregnancy.Royal Society open science · 2017Article
- From tissue to silicon to plastic: three-dimensional printing in comparative anatomy and physiology.Royal Society open science · 2016Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn biomedical sciences, ex vivo angiography is a practical mean to elucidate vascular structures three-dimensionally with simultaneous estimation of intravascular volume. The objectives of this study were to develop a magnetic resonance (MR) method for ex vivo angiography and to compare the findings with computed tomography (CT). To demonstrate the usefulness of this method, examples are provided from four different tissues and species: the human placenta, a rice field eel, a porcine heart and a turtle.
resultsThe optimal solution for ex vivo MR angiography (MRA) was a compound containing gelatine (0.05 g/mL), the CT contrast agent barium sulphate (0.43 mol/L) and the MR contrast agent gadoteric acid (2.5 mmol/L). It was possible to perform angiography on all specimens. We found that ex vivo MRA could only be performed on fresh tissue because formalin fixation makes the blood vessels permeable to the MR contrast agent.
conclusionsEx vivo MRA provides high-resolution images of fresh tissue and delineates fine structures that we were unable to visualise by CT. We found that MRA provided detailed information similar to or better than conventional CTA in its ability to visualize vessel configuration while avoiding interfering signals from adjacent bones. Interestingly, we found that vascular tissue becomes leaky when formalin-fixed, leading to increased permeability and extravascular leakage of MR contrast agent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.