ArticleBMC cancer2010
Quantitative methylation profiling in tumor and matched morphologically normal tissues from breast cancer patients.
Article in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Pooled it
- Quantitative assessment of the association between APC promoter methylation and breast cancer.Oncotarget · 2016Pooled it
- Chimeric RNAs reveal putative neoantigen peptides for developing tumor vaccines for breast cancer.Frontiers in immunology · 2023Article
- Size and Methylation Index of Cell-Free and Cell-Surface-Bound DNA in Blood of Breast Cancer Patients in the Contest of Liquid Biopsy.International journal of molecular sciences · 2022Article
- Salivary DNA Methylation as an Epigenetic Biomarker for Head and Neck Cancer. Part II: A Cancer Risk Meta-Analysis.Journal of personalized medicine · 2021Review
- Molecular Markers in Sex Differences in Cancer.Toxicological research · 2019Review
- Methylation Profiles of BRCA1, RASSF1A and GSTP1 in Vietnamese Women with Breast CancerAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Blood free-circulating DNA testing by highly sensitive methylation assay to diagnose colorectal neoplasias.Oncotarget · 2018Article
- A Metabolomics Pilot Study on Desmoid Tumors and Novel Drug Candidates.Scientific reports · 2018Article
- DFNA5 promoter methylation a marker for breast tumorigenesis.Oncotarget · 2017Article
- Hypermethylation of CDKN2A exon 2 in tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients.BMC cancer · 2017Article
- Article
- Multiple biological functions of Twist1 in various cancers.Oncotarget · 2017Review
- [Promoter methylation and expression of death-associated protein kinase gene in acute leukemia].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Quantitative and correlation analysis of the DNA methylation and expression of DAPK in breast cancer.PeerJ · 2017Article
- Methylation status and protein expression of RASSF1A in breast cancer patients.Molecular biology reports · 2014Article
- Comparison of methylation profiling in cancerous and their corresponding normal tissues from korean patients with breast cancer.Annals of laboratory medicine · 2013Article
- Twist: a molecular target in cancer therapeutics.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Review
- Assessment of DNA methylation status in early stages of breast cancer development.British journal of cancer · 2013Article
- Aberrant promoter CpG methylation and its translational applications in breast cancer.Chinese journal of cancer · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the present study, we determined the gene hypermethylation profiles of normal tissues adjacent to invasive breast carcinomas and investigated whether these are associated with the gene hypermethylation profiles of the corresponding primary breast tumors.
methodsA quantitative methylation-specific PCR assay was used to analyze the DNA methylation status of 6 genes (DAPK, TWIST, HIN-1, RASSF1A, RARbeta2 and APC) in 9 normal breast tissue samples from unaffected women and in 56 paired cancerous and normal tissue samples from breast cancer patients.
resultsNormal tissue adjacent to breast cancer displayed statistically significant differences to unrelated normal breast tissues regarding the aberrant methylation of the RASSF1A (P = 0.03), RARbeta2 (P = 0.04) and APC (P = 0.04) genes. Although methylation ratios for all genes in normal tissues from cancer patients were significantly lower than in the cancerous tissue from the same patient (P < or = 0.01), in general, a clear correlation was observed between methylation ratios measured in both tissue types for all genes tested (P < 0.01). When analyzed as a categorical variable, there was a significant concordance between methylation changes in normal tissues and in the corresponding tumor for all genes tested but RASSF1A. Notably, in 73% of patients, at least one gene with an identical methylation change in cancerous and normal breast tissues was observed.
conclusionsHistologically normal breast tissues adjacent to breast tumors frequently exhibit methylation changes in multiple genes. These methylation changes may play a role in the earliest stages of the development of breast neoplasia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.