Trial reportAnnals of neurology2010
High-frequency electroencephalographic oscillations correlate with outcome of epilepsy surgery.
Trial report in Annals of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 266 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
266 citing papers in PubMed, 5 syntheses or guidelines pooled it, 672 citations in OpenAlex.
- Seizure Outcome After Intraoperative Electrocorticography-Tailored Epilepsy Surgery: A Systematic Review and Meta-Analysis.Neurology · 2024Pooled it
- Prognostic Value of Complete Resection of the High-Frequency Oscillation Area in Intracranial EEG: A Systematic Review and Meta-Analysis.Neurology · 2024Pooled it
- Association between Removal of High-Frequency Oscillations and the Effect of Epilepsy Surgery: A Meta-Analysis.Journal of neurological surgery. Part A, Central European neurosurgery · 2024Pooled it
- Decoding Intracranial EEG With Machine Learning: A Systematic Review.Frontiers in human neuroscience · 2022Pooled it
- The role of high-frequency oscillations in epilepsy surgery planning.The Cochrane database of systematic reviews · 2017Pooled it
- Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial): a randomised, single-blind, adaptive non-inferiority trial.The Lancet. Neurology · 2022Trial
- Removing high-frequency oscillations: A prospective multicenter study on seizure outcome.Neurology · 2018Trial
- Trial
- The Influence of Recording Duration and Vigilance State on High-Frequency Oscillation Characterization in Epilepsy.Neurology · 2026Article
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Sleep enhances gamma oscillations in the seizure onset zone and broadband activity in the irritative zone of focal cortical dysplasia.Epilepsia open · 2026Article
- Predicting surgical outcome in drug-resistant epilepsy by combining interictal biomarkers within a machine learning framework.Scientific reports · 2026Article
- Multimodal integration of magnetic resonance imaging and intracranial electroencephalographic abnormalities in temporal lobe epilepsy surgery.Epilepsia · 2026Article
- Predicting Surgical Outcome in Drug-Resistant Epilepsy by Combining Interictal Biomarkers within a Machine Learning Framework.Research square · 2026Article
- Photothrombosis-induced cortical stroke mouse model produces focal electrographic epileptic human biomarkers.Experimental neurology · 2026Article
- Toward Unified Biomarkers for Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Localizing the epileptogenic zone in drug-resistant epilepsy based on ictal SEEG high-resolution time-frequency representation.Frontiers in neuroscience · 2026Article
- Multi-montage visualization of interictal epileptic events in high-density intraoperative electrocorticography.Clinical neurophysiology practice · 2026Article
- The Top 100 Most Cited Articles on Epilepsy Surgery: A Bibliometric Analysis of the Literature.Cureus · 2025Review
- Self-supervised data-driven approach defines pathological high-frequency oscillations in epilepsy.Epilepsia · 2025Article
206 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveHigh-frequency oscillations (HFOs) in the intracerebral electroencephalogram (EEG) have been linked to the seizure onset zone (SOZ). We investigated whether HFOs can delineate epileptogenic areas even outside the SOZ by correlating the resection of HFO-generating areas with surgical outcome.
methodsTwenty patients who underwent a surgical resection for medically intractable epilepsy were studied. All had presurgical intracerebral EEG (500Hz filter and 2,000Hz sampling rate), at least 12-month postsurgical follow-up, and a postsurgical magnetic resonance imaging (MRI). HFOs (ripples, 80-250Hz; fast ripples, >250Hz) were identified visually during 5 to 10 minutes of slow-wave sleep. Rates and extent of HFOs and interictal spikes in resected versus nonresected areas, assessed on postsurgical MRIs, were compared with surgical outcome (Engel's classification). We also evaluated the predictive value of removing the SOZ in terms of surgical outcome.
resultsThe mean duration of follow-up was 22.7 months. Eight patients had good (Engel classes 1 and 2) and 12 poor (classes 3 and 4) surgical outcomes. Patients with a good outcome had a significantly larger proportion of HFO-generating areas removed than patients with a poor outcome. No such difference was seen for spike-generating regions or the SOZ.
interpretationThe correlation between removal of HFO-generating areas and good surgical outcome indicates that HFOs could be used as a marker of epileptogenicity and may be more accurate than spike-generating areas or the SOZ. In patients in whom the majority of HFO-generating tissue remained, a poor surgical outcome occurred.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.