ArticlePloS one2010
Human mammary epithelial cells exhibit a bimodal correlated random walk pattern.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Enteropathogenic Escherichia coli induces Entamoeba histolytica superdiffusion movement on fibronectin by reducing traction forces.PLoS pathogens · 2025Article
- pERK transition-induced directional mode switching promotes epithelial tumor cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Topological data analysis of spatial patterning in heterogeneous cell populations: clustering and sorting with varying cell-cell adhesion.NPJ systems biology and applications · 2023Article
- The recent advances in the mathematical modelling of human pluripotent stem cells.SN applied sciences · 2020Review
- Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo.Nature communications · 2018Article
- Collective regulation of cell motility using an accurate density-sensing system.Journal of the Royal Society, Interface · 2018Article
- Anomalous diffusion and q-Weibull velocity distributions in epithelial cell migration.PloS one · 2017Article
- Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration.Scientific reports · 2016Article
- Superstatistical analysis and modelling of heterogeneous random walks.Nature communications · 2015Article
- Characterization of anomalous movements of spherical living cells on a silicon dioxide glassy substrate.Biomicrofluidics · 2015Article
- Unimodal and bimodal random motions of independent exponential steps.The European physical journal. E, Soft matter · 2014Article
- Quantitative and unbiased analysis of directional persistence in cell migration.Nature protocols · 2014Article
- Article
- P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.Immunology and cell biology · 2013Article
- Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model.Advances in hematology · 2012Article
- Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces.Journal of cell science · 2011Article
- A quorum-sensing factor in vegetative Dictyostelium discoideum cells revealed by quantitative migration analysis.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundOrganisms, at scales ranging from unicellular to mammals, have been known to exhibit foraging behavior described by random walks whose segments confirm to Lévy or exponential distributions. For the first time, we present evidence that single cells (mammary epithelial cells) that exist in multi-cellular organisms (humans) follow a bimodal correlated random walk (BCRW). METHODOLOGY/PRINCIPAL
findingsCellular tracks of MCF-10A pBabe, neuN and neuT random migration on 2-D plastic substrates, analyzed using bimodal analysis, were found to reveal the BCRW pattern. We find two types of exponentially distributed correlated flights (corresponding to what we refer to as the directional and re-orientation phases) each having its own correlation between move step-lengths within flights. The exponential distribution of flight lengths was confirmed using different analysis methods (logarithmic binning with normalization, survival frequency plots and maximum likelihood estimation). CONCLUSIONS/SIGNIFICANCE: Because of the presence of non-uniform turn angle distribution of move step-lengths within a flight and two different types of flights, we propose that the epithelial random walk is a BCRW comprising of two alternating modes with varying degree of correlations, rather than a simple persistent random walk. A BCRW model rather than a simple persistent random walk correctly matches the super-diffusivity in the cell migration paths as indicated by simulations based on the BCRW model.
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