ArticlePloS one2010
Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 93 citations in OpenAlex.
- Human genetic variations conferring resistance to malaria.Journal of translational medicine · 2025Review
- IFN‑γ Production in Memory CD4ACS omega · 2025Article
- IDO1-AhR axis increases T regulatory cells inFrontiers in immunology · 2025Article
- Evaluation of immunophenotypic alterations of peripheral blood lymphocytes and their sub-sets in uncomplicated P. Falciparum infection.BMC immunology · 2024Article
- Integrated Analysis of Cytokine Profiles in Malaria Patients Discloses Selective Upregulation of TGF-β1, β3, and IL-9 in Mild Clinical Presentation.International journal of molecular sciences · 2022Article
- Impact of immune checkpoint molecules on FoxP3BMC infectious diseases · 2021Article
- Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid.Clinical and experimental immunology · 2019Article
- Effect of Cytotoxic T-Lymphocyte Antigen-4 on the Efficacy of the Fatty Acid-Binding Protein Vaccine AgainstFrontiers in immunology · 2019Article
- Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines.Frontiers in immunology · 2019Review
- Malaria systems immunology: Plasmodium vivax induces tolerance during primary infection through dysregulation of neutrophils and dendritic cells.The Journal of infection · 2018Article
- Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria.The Journal of infectious diseases · 2018Article
- Analysis of the lymphocyte cell population during malaria caused by Plasmodium vivax and its correlation with parasitaemia and thrombocytopaenia.Malaria journal · 2018Article
- The Contribution of Co-signaling Pathways to Anti-malarial T Cell Immunity.Frontiers in immunology · 2018Review
- Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1cInfection and immunity · 2017Article
- On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease.Malaria journal · 2017Article
- Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis.Frontiers in immunology · 2017Review
- Pro- and anti-inflammatory cytokines in children with malaria in Franceville, Gabon.American journal of clinical and experimental immunology · 2017Article
- Surface expression of inhibitory (CTLA-4) and stimulatory (OX40) receptors by CD4Microbes and infection · 2016Article
- Polymorphisms in Plasmodium vivax Circumsporozoite Protein (CSP) Influence Parasite Burden and Cytokine Balance in a Pre-Amazon Endemic Area from Brazil.PLoS neglected tropical diseases · 2016Article
- Interleukin 10 and dendritic cells are the main suppression mediators of regulatory T cells in human neurocysticercosis.Clinical and experimental immunology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulation CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) have been associated with the delicate balancing between control of overwhelming acute malaria infection and prevention of immune pathology due to disproportionate inflammatory responses to erythrocytic stage of the parasite. While the role of Tregs has been well-documented in murine models and P. falciparum infection, the phenotype and function of Tregs in P. vivax infection is still poorly characterized. In the current study, we demonstrated that patients with acute P. vivax infection presented a significant augmentation of circulating Tregs producing anti-inflammatory (IL-10 and TGF-beta) as well as pro-inflammatory (IFN-gamma, IL-17) cytokines, which was further positively correlated with parasite burden. Surface expression of GITR molecule and intracellular expression of CTLA-4 were significantly upregulated in Tregs from infected donors, presenting also a positive association between either absolute numbers of CD4(+)CD25(+)FoxP3(+)GITR(+) or CD4(+)CD25(+)FoxP3(+)CTLA-4(+) and parasite load. Finally, we demonstrate a suppressive effect of Treg cells in specific T cell proliferative responses of P. vivax infected subjects after antigen stimulation with Pv-AMA-1. Our findings indicate that malaria vivax infection lead to an increased number of activated Treg cells that are highly associated with parasite load, which probably exert an important contribution to the modulation of immune responses during P. vivax infection.
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