ArticleInternational journal of biological sciences2010
Aberrant leukocyte infiltration: a direct trigger for breast tumor invasion and metastasis.
Article in International journal of biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 19 citations in OpenAlex.
- Thrombin-Activated Platelets Protect Vascular Endothelium against Tumor Cell Extravasation by Targeting Endothelial VCAM-1.International journal of molecular sciences · 2022Article
- Article
- A quantitative proteomics analysis of MCF7 breast cancer stem and progenitor cell populations.Proteomics · 2015Article
- The "cavitary" type of angiogenesis by gastric cancer. Morphological characteristics and prognostic value.Journal of Cancer · 2014Article
- Tumor-infiltrating immune cells: triggers for tumor capsule disruption and tumor progression?International journal of medical sciences · 2013Article
- Tumor-infiltrating immune cells promoting tumor invasion and metastasis: existing theories.Journal of Cancer · 2013Article
- Putative biomarkers and targets of estrogen receptor negative human breast cancer.International journal of molecular sciences · 2011Review
- Leukocyte infiltration as a surrogate marker for diagnosis of invasion.International journal of biological sciences · 2010Article
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Abstract
Our previous studies revealed that leukocyte infiltration could trigger breast and prostate tumor invasion through physical disruption of tumor capsules. Our current study, involving multiple types of human tumors, further suggests that leukocyte infiltration also triggers metastasis through the following pathways : 1) the physical movement into the epithelium disrupts inter-cellular junctions and surface adhesion molecules, which cause the disassociation of tumor cells from tumor cores, 2) some of these tumor cells subsequently form tight junctions with the plasma membranes of leukocytes creating tumor cell-leukocyte chimeras (TLCs), and 3) the leukocytes of TLCs impart migratory capacity to associated tumor cell partners. Our findings suggest a novel pathway for tumor cell dissemination from primary sites and journey to new sites.
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