ArticleInternational journal of clinical and experimental pathology2010
Molecular detection of B-cell neoplasms by specific DNA methylation biomarkers.
Article in International journal of clinical and experimental pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Article
- Identification of DNA methylation associated gene signatures in endometrial cancer via integrated analysis of DNA methylation and gene expression systematically.Journal of gynecologic oncology · 2017Article
- Epigenetic regulation of the circadian clock: role of 5-aza-2'-deoxycytidine.Bioscience reports · 2017Article
- The expression of RUNDC3B is associated with promoter methylation in lymphoid malignancies.Hematological oncology · 2017Article
- Whole-genome DNA methylation characteristics in pediatric precursor B cell acute lymphoblastic leukemia (BCP ALL).PloS one · 2017Article
- DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission.PloS one · 2012Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
A novel, easy to perform PCR-based method employing specific DNA methylation biomarkers to detect B-cell neoplasms in a variety of B-cell lines and B lymphoblastic leukemia (B-ALL) patient specimens has been developed. This method detects as few as 5 B-ALL cells, or 1 B-ALL cell in 1,000,000 normal background blood cells using a single marker, DLC-1 gene CpG island (CGI) methylation. By adding two additional markers PCDHGA12 and RPIB9, over 80% of B-ALL cases were detected in patients' bone marrow and/or peripheral blood specimens. We have traced clinical B-ALL cases up to 10 years retrospectively and the DLC-1 methylation is correlated with patient clinical status. Thus, this epigenetic-based molecular method demonstrates its potential use in the diagnosis of B-cell neoplasia, in addition to traditional approach such as clinical features, morphology, immunophenotype, and genetic analysis.
Indexed as
Identifiers
20224725PMC2836504W49371899What OpenQuestion holds
Registered trials
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