ArticleDermato-endocrinology2009
Overexpression of CXCL16 in lesional psoriatic skin.
Article in Dermato-endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- T cell receptor signaling strength establishes the chemotactic properties of effector CD8Nature communications · 2023Article
- TLR7-MyD88-DC-CXCL16 axis results neutrophil activation to elicit inflammatory response in pustular psoriasis.Cell death & disease · 2023Article
- Inflammation-mediated fibroblast activation and immune dysregulation in collagen VII-deficient skin.Frontiers in immunology · 2023Article
- Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells.Frontiers in immunology · 2022Article
- T-cell positioning by chemokines in autoimmune skin diseases.Immunological reviews · 2019Review
- Chemokine Regulation of Angiogenesis During Wound Healing.Advances in wound care · 2015Review
- Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin.PloS one · 2014Article
- Plasmacytoid dendritic cell response to CpG ODN correlates with CXCL16 expression and is inhibited by ox-LDL.Mediators of inflammation · 2013Article
- Natural killer cell memory.Nature immunology · 2011Review
- The human cutaneous chemokine system.Frontiers in immunology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsoriasis is characterized as an autoimmune disease resulting in an exaggerated innate immune response. The CXC-chemokine ligand 16 (CXCL16) is described to function as an adhesion molecule, a scavenger receptor or as a soluble molecule it acts as a chemoattractant. CXCL16 has been reported to be expressed in a variety of inflammatory diseases. However, no information has been reported in the literature about the expression of CXCL16 in psoriatic skin. PURPOSE: The present study was designed to analyze the expression and localization of CXCL16 in human psoriatic skin tissues.
resultsIn normal skin, cytpoplasmic expression of CXCL16 was increased in keratinocytes of upper epidermal cell layers as compared to the lower epidermal cell layers. In lesional psoriatic skin, CXCL16 immunoreactivity was increased in the cytoplasm of keratinocytes of lower epidermal layer kerartinocytes as compared to the normal epidermis. Cytoplasmic CXCL16 expression was increased in the capillary endothelial cells of psoriatic dermis as compared to capillary endothelial cells of the normal dermis. Notably, almost all inflammatory cells in the dermis were negative for CXCL16. MATERIALS AND
methodsTen paraffinized specimens of human lesional psoriatic skin and five paraffinized specimens of normal skin were studied using an immunohistochemical streptavidinperoxidase technique.
conclusionWe here report for the first time alterations in the immunohistochemical staining pattern of CXCL16 in lesional psoriatic skin compared to the normal skin. These results suggest that CXCL16 may play a role in the pathogenesis of psoriasis.
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