ArticleRetina (Philadelphia, Pa.)
Fundus autofluorescence, optical coherence tomography, and electroretinogram findings in choroidal sclerosis.
Article in Retina (Philadelphia, Pa.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- Predicting visual acuity in Bietti crystalline dystrophy: evaluation of image parameters.BMC ophthalmology · 2021Article
- Multicolor imaging in central serous chorioretinopathy - a quantitative and qualitative comparison with fundus autofluorescence.Scientific reports · 2019Article
- Clinical characteristics of a large choroideremia pedigree carrying a novel CHM mutation.Archives of ophthalmology (Chicago, Ill. : 1960) · 2012Article
- Two-photon excited autofluorescence imaging of freshly isolated frog retinas.Biomedical optics express · 2011Article
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4 authors at 1 institution in 1 country.
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Abstract
purposeThe purpose of this study was to describe fundus autofluorescence (FAF), optical coherence tomography, and electroretinogram findings in choroidal sclerosis.
methodsThis is a retrospective case series. Eight eyes of four patients with choroidal sclerosis were evaluated with FAF, optical coherence tomography, and electroretinogram testing.
resultsIn all eight eyes, FAF imaging showed hypofluorescent placoid lesions corresponding to areas of chorioretinal atrophy seen on stereo biomicroscopy. Prominent hyperfluorescent linear markings underlying regions of atrophic disease were observed in all eyes, likely representative of normal choroidal vessel autofluorescence. In two eyes, FAF showed punctate hypofluorescent lesions in the fovea that were not visualized on biomicroscopy. In one eye, FAF identified a central island of preserved retinal pigment epithelium that was not realized on ophthalmoscopic examination. Optical coherence imaging was significant for loss of choroidal fine tubular structures, retinal pigment epithelium, and outer nuclear layer in regions of chorioretinal atrophy. Full-field electroretinogram testing showed generalized rod-cone dysfunction in all patients with a lower B- to A-wave ratio in two patients.
conclusionFundus autofluorescence and optical coherence tomography are nonin-vasive diagnostic adjuncts that can aid in the diagnosis of choroidal sclerosis. Fundus autofluorescence may be a more sensitive marker of disease extent and progression than clinical examination alone. Electroretinogram testing can result in an electronegative maximal response.
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