ArticleThe journal of medical investigation : JMI2009
Aquaporin water channels in transepithelial fluid transport.
Article in The journal of medical investigation : JMI, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- The Role of Aquaporin 4 in Lacrimal Gland Ductal Fluid Secretion in Mice.Investigative ophthalmology & visual science · 2024Article
- Role of Aquaporins in Spermatogenesis and Testicular Steroidogenesis.The Journal of membrane biology · 2020Review
- The Importance of Aquaporin 1 in Pancreatitis and Its Relation to the CFTR ClFrontiers in physiology · 2018Article
- Microfluidic platform for rapid measurement of transepithelial water transport.Lab on a chip · 2017Article
- Expression, Distribution and Role of Aquaporin Water Channels in Human and Animal Stomach and Intestines.International journal of molecular sciences · 2016Review
- Aquaporins in Health and Disease: An Overview Focusing on the Gut of Different Species.International journal of molecular sciences · 2016Review
- Endothelial Aquaporin-1 (AQP1) Expression Is Regulated by Transcription Factor Mef2c.Molecules and cells · 2016Article
- [AQP5 gene silencing inhibits proliferation and migration of ectopic endometrial glandular epithelial cells in endometriosis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2015Article
- Down-regulation of aquaporin3 expression by lipopolysaccharide via p38/c-Jun N-terminal kinase signalling pathway in HT-29 human colon epithelial cells.World journal of gastroenterology · 2015Article
- Polyphenols as Modulators of Aquaporin Family in Health and Disease.Oxidative medicine and cellular longevity · 2015Review
- Focus on molecular events in the anterior chamber leading to glaucoma.Cellular and molecular life sciences : CMLS · 2014Review
- Genetic deletion of aquaporin-1 results in microcardia and low blood pressure in mouse with intact nitric oxide-dependent relaxation, but enhanced prostanoids-dependent relaxation.Pflugers Archiv : European journal of physiology · 2014Article
- Overexpression of aquaporin 1 in the tunica vaginalis may contribute to adult-onset primary hydrocele testis.Advances in urology · 2014Article
- Membrane transporters in a human genome-scale metabolic knowledgebase and their implications for disease.Frontiers in physiology · 2014Review
- Decrease of renal aquaporins 1-4 is associated with renal function impairment in pediatric congenital hydronephrosis.World journal of pediatrics : WJP · 2012Article
- Increased differentiation capacity of bone marrow-derived mesenchymal stem cells in aquaporin-5 deficiency.Stem cells and development · 2012Article
- Aquaporins in clinical medicine.Annual review of medicine · 2012Review
- Molecular profiling of the human nasal epithelium: A proteomics approach.Journal of proteomics · 2011Article
- Changes of aquaporins in the lacrimal glands of a rabbit model of Sjögren's syndrome.Current eye research · 2011Article
- Changes of the ocular surface and aquaporins in the lacrimal glands of rabbits during pregnancy.Molecular vision · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Aquaporins (AQPs) are membrane water channels that are involved in a diverse set of functions in mammalian physiology including epithelial fluid transport, brain water balance, cell migration, cell proliferation, neuroexcitation, fat metabolism, epidermal hydration, and others. Phenotype analysis of knockout mice has demonstrated an important role for AQPs in transepithelial fluid transport in kidney tubules, salivary and airway submucosal glands, choroid plexus and ciliary epithelium. The physiological functions of these epithelia, such as absorption of glomerular filtrate by proximal tubule and secretion of saliva by salivary gland, involve rapid transcellular water transport across epithelial cell barriers. Studies in knockout mice have also provided evidence that AQPs are not physiologically important in some epithelia where they are expressed, including lacrimal gland, sweat gland, gallbladder, alveoli and airways. Rates of transepithelial fluid transport per unit membrane surface area in these epithelia are substantially lower than transepithelial fluid transport rates in proximal tubule and salivary gland. Pharmacological inhibition of AQP water permeability in epithelia, with consequent reduced fluid transport, offers potential therapy for human diseases involving water imbalance such as congestive heart failure, hypertension and glaucoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.