ArticleMolecular biology and evolution2010
The demographic histories of the M and S molecular forms of Anopheles gambiae s.s.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 33 citations in OpenAlex.
- Whole-genome sequencing of major malaria vectors reveals the evolution of new insecticide resistance variants in a longitudinal study in Burkina Faso.Malaria journal · 2024Article
- Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria Exposure.American journal of human genetics · 2019Article
- Chromosomal inversions and ecotypic differentiation in Anopheles gambiae: the perspective from whole-genome sequencing.Molecular ecology · 2016Article
- An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors.PLoS pathogens · 2015Article
- Equivalent susceptibility of Anopheles gambiae M and S molecular forms and Anopheles arabiensis to Plasmodium falciparum infection in Burkina Faso.Malaria journal · 2013Article
- Entomological surveillance of behavioural resilience and resistance in residual malaria vector populations.Malaria journal · 2013Article
- Interactions of Anopheles gambiae odorant-binding proteins with a human-derived repellent: implications for the mode of action of n,n-diethyl-3-methylbenzamide (DEET).The Journal of biological chemistry · 2013Article
- Article
- Evidence for population-specific positive selection on immune genes of Anopheles gambiae.G3 (Bethesda, Md.) · 2012Article
- No evidence for biased co-transmission of speciation islands in Anopheles gambiae.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Article
- The effective population size of malaria mosquitoes: large impact of vector control.PLoS genetics · 2012Article
- Patterns of genomic differentiation between ecologically differentiated M and S forms of Anopheles gambiae in West and Central Africa.Genome biology and evolution · 2012Article
- Assessing the accuracy and power of population genetic inference from low-pass next-generation sequencing data.Frontiers in genetics · 2012Article
- Molecular evolution of a gene cluster of serine proteases expressed in the Anopheles gambiae female reproductive tract.BMC evolutionary biology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Anopheles gambiae is a primary vector of Plasmodium falciparum, a human malaria parasite that causes over a million deaths each year in sub-Saharan Africa. Population genetic tests have been employed to detect natural selection at suspected A. gambiae antimalaria genes, but these tests have generally been compromised by the lack of demographically correct null models. Here, we used a coalescent simulation approach within a maximum likelihood framework to fit population growth, bottleneck, and migration models to polymorphism data from Cameroonian A. gambiae. The best-fit models for both the "M" and the "S" molecular forms of A. gambiae included ancient population growth and a high rate of migration from an unsampled subpopulation. After correcting for differences in effective population size, our models suggest that the molecular forms expanded at different times and both expansions significantly predate the advent of agriculture. We show that correcting null models for demography increases the power to detect natural selection in A. gambiae.
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