Evidence map›Paper›PMID 20223736›Full record

ArticleInternational journal of bioinformatics research and applications2010

Flavitrack analysis of the structure and function of West Nile non-structural proteins.

Petr Danecek, Catherine H Schein

Open access · greenAbstract read
In one paragraph

Article in International journal of bioinformatics research and applications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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  5. Allosteric inhibitors of Coxsackie virus A24 RNA polymerase.Bioorganic & medicinal chemistry · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Petr DanecekSealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555-0857, USA. pd3@sanger.ac.uk
Catherine H Schein
John Sealy Hospital · USThe University of Texas Medical Branch at Galveston · US

Funding

Computational tools for T- and B-cell epitope predictionR01AI064913 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BRAUN, WERNER A · 2005 to 2010
$1.6M
Predicting cross-reactivity of protein antigens using 3D motifsR56AI064913 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRAUN, WERNER A · 2011 to 2011
$340k
NIAID NIH HHS AI064913NIAID NIH HHS R01 AI064913NIAID NIH HHS R56 AI064913
6 · The paper itself

Abstract

The Flavitrack database groups Flaviviruses (FV), evolutionarily related organisms with high subtype variability, according to their phenotypes. Here, PCPMer tools were used to calculate consensus sequences based on conservation of Physicochemical Properties (PCP) for 919 sequences of NS2a, a non-structural protein involved in preventing host interferon response to infection. Conserved PCP-motifs were detected, primarily in the N-terminal half of NS2a. One model structure, based on a nuclear receptor, groups residues essential for West Nile (WN) infectivity (I59, V61, and M103) in a pocket on the protein surface. These methods will aid in the design of vaccines and specific therapies against FV.

Indexed as

Amino Acid SequenceComputational BiologyDatabases, GeneticFlavivirusGenome, ViralMolecular Sequence DataProtein ConformationViral Nonstructural ProteinsVirus ReplicationWest Nile FeverViral Nonstructural Proteins

Identifiers

PMID20223736
PMCPMC2849288
OpenAlexW2156773176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.