Evidence map›Paper›PMID 20223605›Full record

ReviewThe Journal of hand surgery2010

Compressive neuropathies of the upper extremity: update on pathophysiology, classification, and electrodiagnostic findings.

Minal Tapadia, Tahseen Mozaffar, Ranjan Gupta

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of hand surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 105 citations in OpenAlex.

  1. Article
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  4. Review
  5. Occupational nerve injuries.Muscle & nerve · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Minal TapadiaUniversity of California, Irvine, Irvine, CA 92697, USA.
Tahseen Mozaffar
Ranjan Gupta
University of California, Irvine · US

Funding

Schwann cell regulation of chronic nerve injuryR01NS049203 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GUPTA, RANJAN · 2004 to 2014
$3.1M
NINDS NIH HHS R01 NS049203
6 · The paper itself

Abstract

Clinical examination and electrodiagnostic studies remain the gold standard for diagnosis of nerve injuries. Diagnosis of chronic nerve compression (CNC) injuries can be difficult in patients with confounding factors such as diabetes. The treatment of nerve entrapment ranges from medical to surgical management, depending on the nerve involved and on the severity and duration of compression. Considerable insights have been made at the molecular level, differentiating between nerve crush injuries and CNC injuries. Although the myelin changes after CNC injury were previously thought to be a mild form of Wallerian degeneration, recent evidence points to a distinct pathophysiology involving Schwann cell mechanosensitivity. Future areas of research include Schwann cell transplantation in the treatment regimen, the correlation between demyelination and the onset of pain, and the role of Schwann cell integrins in transducing the mechanical forces involved in nerve compression injuries to Schwann cells.

Indexed as

Peripheral Nerve InjuriesCell ProliferationDiabetic NeuropathiesElectrodiagnosisHumansNerve Compression SyndromesNerve RegenerationPeripheral NervesSchwann CellsUpper Extremity

Identifiers

PMID20223605
PMCPMC4715364
OpenAlexW2059804126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.