Evidence map›Paper›PMID 20223514›Full record

ArticleLancet (London, England)2010

Infection-related stillbirths.

Robert L Goldenberg, Elizabeth M McClure, Sarah Saleem, Uma M Reddy

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Lancet (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03438110 (Project to Understand & Research Preterm Pregnancy Outcomes-South Asia), which is not on this map. Cited by 100 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 6 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03438110 completednot on this mapstarted 2018, after this paper: background citation

Project to Understand & Research Preterm Pregnancy Outcomes-South Asia (PURPOSe)

TypeobservationalSponsorRTI InternationalRan2018 to 2020Enrolled1,226ConditionsNeonatal Death, Stillbirth
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 6 syntheses or guidelines pooled it, 235 citations in OpenAlex.

  1. Pooled it
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  4. Stillbirth With Group B Streptococcus Disease Worldwide: Systematic Review and Meta-analyses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Pooled it
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  7. Trial
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  14. Review
  15. Diagnostic evaluation to identify infection-attributable stillbirth.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  16. Article
  17. Article
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  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Robert L GoldenbergDrexel University College of Medicine, Philadelphia, PA 19102, USA. rgoldenb@drexelmed.edu
Elizabeth M McClure
Sarah Saleem
Uma M Reddy
Aga Khan University · PKDrexel University · USNational Institutes of Health · USUniversity of North Carolina at Chapel Hill · US

Funding

Zika in Pregnancy Supplemental Funding requestU01HD040636 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI MCCLURE, ELIZABETH M · 2001 to 2017
$37.5M
Global Network for Women's and Children's Health Research Data Coordinating CenterU24HD092094 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Elizabeth M McClure · 2017 to 2026
$17.8M
UAB/AKU Global Network Research UnitU01HD040607 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOLDENBERG, ROBERT L · 2001 to 2012
$8.5M
NICHD NIH HHS U01 HD040607NICHD NIH HHS U01 HD040636NICHD NIH HHS U24 HD092094
6 · The paper itself

Abstract

Infection is an important cause of stillbirths worldwide: in low-income and middle-income countries, 50% of stillbirths or more are probably caused by infection. By contrast, in high-income countries only 10-25% of stillbirths are caused by infection. Syphilis, where prevalent, causes most infectious stillbirths, and is the infection most amenable to screening and treatment. Ascending bacterial infection is a common cause of stillbirths, but prevention has proven elusive. Many viral infections cause stillbirths but aside from vaccination for common childhood diseases, we do not have a clear prevention strategy. Malaria, because of its high prevalence and extensive placental damage, accounts for large numbers of stillbirths. Intermittent malarial prophylaxis and insecticide-treated bednets should decrease stillbirths. Many infections borne by animals and vectors cause stillbirths, and these types of infections occur frequently in low-income countries. Research that better defines the relation between these infections and stillbirths, and develops strategies to reduce associated adverse outcomes, should play an important part in reduction of stillbirths in low-income countries.

Indexed as

Developed CountriesDeveloping CountriesPregnancy Complications, InfectiousStillbirthFemaleHumansInfant, NewbornPregnancyPregnancy Outcome

Identifiers

PMID20223514
PMCPMC3893931
OpenAlexW2132102990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.