ArticleAtherosclerosis2010
Variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults.
Article in Atherosclerosis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01231958 (The Boston Puerto Rican Health Study), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Boston Puerto Rican Health Study: Center for Population Health and Health Disparities
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults.Scientific reports · 2022Pooled it
- Dietary fat modulation of hepatic lipase variant -514 C/T for lipids: a crossover randomized dietary intervention trial in Caribbean Hispanics.Physiological genomics · 2017Trial
- CD36 and Its Role in Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Genotypic and Allelic Distribution of theGenes · 2024Article
- Genetic Variants inNutrients · 2023Article
- Common variants in the CD36 gene are associated with dietary fat intake, high-fat food consumption and serum triglycerides in a cohort of Quebec adults.International journal of obesity (2005) · 2021Article
- Polymorphisms of peroxisome proliferator-activated receptor γ (PPARγ) and cluster of differentiation 36 (CD36) associated with valproate-induced obesity in epileptic patients.Psychopharmacology · 2018Article
- Associations between CD36 gene polymorphisms, fat tolerance and oral fat preference in a young-adult population.European journal of clinical nutrition · 2016Article
- Association between rs1761667 polymorphism of CD36 gene and risk of coronary atherosclerosis in Egyptian population.Cardiovascular diagnosis and therapy · 2016Article
- Deregulated Lipid Sensing by Intestinal CD36 in Diet-Induced Hyperinsulinemic Obese Mouse Model.PloS one · 2016Article
- Associations between CD36 gene polymorphisms and susceptibility to coronary artery heart disease.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Article
- CD36 haplotypes are associated with lipid profile in normal-weight subjects.Lipids in health and disease · 2013Article
- CD36 protein influences myocardial Ca2+ homeostasis and phospholipid metabolism: conduction anomalies in CD36-deficient mice during fasting.The Journal of biological chemistry · 2012Article
- Metabolic syndrome is linked to chromosome 7q21 and associated with genetic variants in CD36 and GNAT3 in Mexican Americans.Obesity (Silver Spring, Md.) · 2012Article
- CD36-deficient congenic strains show improved glucose tolerance and distinct shifts in metabolic and transcriptomic profiles.Heredity · 2012Article
- Cholesterol, Inflammasomes, and Atherogenesis.Current cardiovascular risk reports · 2012Article
- CD36 genetics and the metabolic complications of obesity.Current opinion in clinical nutrition and metabolic care · 2011Review
- Article
- Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile.Human molecular genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivePuerto Ricans experience a high prevalence of several chronic conditions, including metabolic syndrome. Genetic variants of the CD36 gene have been associated with metabolic syndrome. We aimed to determine the association between 6 single nucleotide polymorphisms (SNPs) for CD36 and metabolic syndrome and its components in Puerto Ricans (45-75 year) living in the Greater Boston area.
methodsAssociations between each SNP, metabolic syndrome and its components were examined using multivariate logistic regression models. Haplotype trend regression analysis was used to determine associations between haplotypes and metabolic syndrome.
resultsFor two SNPs of CD36 (rs1049673 and rs3211931), homozygous subjects of the minor allele (G and T, respectively) were associated with a higher likelihood of metabolic syndrome (odds ratio (OR) (95% confidence interval (CI)): 1.89 (1.0, 3.5) and 1.77 (1.0, 3.1), respectively) relative to carriers of the major allele. Although CD36 haplotypes were not significantly associated with metabolic syndrome overall (global significance, P=0.23), one haplotype (G-C-C vs. C-C-C (reference haplotype)) was marginally associated (P=0.049).
conclusionSNPs of CD36 were associated with metabolic syndrome in Puerto Ricans. Prospective studies should further explore the role of CD36 variants in the development of this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.