ArticleJournal of insect physiology2010
The members of bHLH transcription factor superfamily are required for female reproduction in the red flour beetle, Tribolium castaneum.
Article in Journal of insect physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Histone and N-terminal acetyltransferases play important roles in female reproduction and embryogenesis of the red flour beetle Tribolium castaneum.Insect molecular biology · 2025Article
- RNAi turns 25:contributions and challenges in insect science.Frontiers in insect science · 2023Review
- Seminal fluid proteins induce transcriptome changes in the Aedes aegypti female lower reproductive tract.BMC genomics · 2021Article
- Genome-enabled insights into the biology of thrips as crop pests.BMC biology · 2020Article
- Multiple functions of CREB-binding protein during postembryonic development: identification of target genes.BMC genomics · 2017Article
- Two adjacent cis-regulatory elements are required for ecdysone response of ecdysone receptor (EcR) B1 transcription.PloS one · 2012Article
- Sex determination in beetles: production of all male progeny by parental RNAi knockdown of transformer.Scientific reports · 2012Article
- The function of nuclear receptors in regulation of female reproduction and embryogenesis in the red flour beetle, Tribolium castaneum.Journal of insect physiology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Proteins containing the basic Helix-Loop-Helix (bHLH) domain function as transcription factors and play important roles during the development of various metazoans including insects, nematodes and vertebrates. Insect genomes contain more than 50 bHLH transcription factors, but the function of only a few of these proteins in regulation of female reproduction is known. Using RNA interference, we have tested knock-down in the expression of genes coding for bHLH transcription factors in newly emerged adult females to determine their function in regulation of female reproduction in the red flour beetle, Tribolium castaneum. Knock-down in the expression of genes coding for four bHLH transcription factors (TcSRC, TcSim1, TcAsh and TcDaughterless) caused mortality in the female beetles. In addition, knocking-down the expression of 16 bHLH genes affected oogenesis and knock-down in the expression of 13 genes affected embryogenesis. Two genes TcSide1 and TcSpineless are required for both oogenesis and embryogenesis. Thus, the data reported here showed that 31 bHLH transcription factors are required for female survival, reproduction and embryogenesis.
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