ArticleNeuron2010
Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior.
Article in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
166 citing papers in PubMed, 1 synthesis or guideline pooled it, 274 citations in OpenAlex.
- Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism.Scientific reports · 2017Pooled it
- Cellular and functional dissection of the octopaminergic and tyraminergic system in the Drosophila brain.Current biology : CB · 2026Article
- CREB promotes starvation-induced sleep loss by regulating octopamine production in Drosophila.Biology open · 2026Article
- Octopamine regulates neural circuits in the mushroom body and central complex, influencing sleep and arousal.iScience · 2026Article
- Dietary unsaturated fatty acids distinctly associate with the early age sleep-wake cycle and gut integrity in aged fruit flies, Drosophila melanogaster.Biogerontology · 2026Article
- Molecular evolution of octopamine receptors in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Octopamine receptors inFrontiers in molecular neuroscience · 2026Article
- Sleep regulation inFrontiers in neuroscience · 2026Review
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Molecular evolution of octopamine receptors inbioRxiv : the preprint server for biology · 2025Article
- Control of Aedes albopictus populations by silencing of the vesicular GABA transporter (vgat) and the vesicular monoamine transporter (vmat) genes using recombinant Chlorella shRNA.Parasites & vectors · 2025Article
- Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells.The Journal of physiology · 2025Article
- Supplementation of essential amino acids suppresses age-associated sleep loss and sleep fragmentation but not loss of rhythm strength under yeast-restricted malnutrition in Drosophila.Journal of biochemistry · 2025Article
- CaActa physiologica (Oxford, England) · 2025Article
- Intermittent Vibration Induces Sleep via an Allatostatin A-GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles.Nature · 2024Article
- Activity Monitoring for Analysis of Sleep inCold Spring Harbor protocols · 2024Article
- Elevated sleep quota in a stress-resilient Drosophila species.Current biology : CB · 2024Article
- Octopaminergic descending neurons inHeliyon · 2024Article
- Octopamine in the mushroom body circuitry for learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
106 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
An understanding of sleep requires the identification of distinct cellular circuits that mediate the action of specific sleep:wake-regulating molecules, but such analysis has been very limited. We identify here a circuit that underlies the wake-promoting effects of octopamine in Drosophila. Using MARCM, we identified the ASM cells in the medial protocerebrum as the wake-promoting octopaminergic cells. We then blocked octopamine signaling in random areas of the fly brain and mapped the postsynaptic effect to insulin-secreting neurons of the pars intercerebralis (PI). These PI neurons show altered potassium channel function as well as an increase in cAMP in response to octopamine, and genetic manipulation of their electrical excitability alters sleep:wake behavior. Effects of octopamine on sleep:wake are mediated by the cAMP-dependent isoform of the OAMB receptor. These studies define the cellular and molecular basis of octopamine action and suggest that the PI is a sleep:wake-regulating neuroendocrine structure like the mammalian hypothalamus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.