ArticleApplied spectroscopy2010
Near-infrared micro-Raman spectroscopy for in vitro detection of cervical cancer.
Article in Applied spectroscopy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 122 citations in OpenAlex.
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- Raman spectroscopy reveals growth phase-dependent molecular differences in bacterial membrane vesicles.Journal of bacteriology · 2026Article
- Raman microspectroscopy for cervical cancer diagnosis: an ex-vivo cryopreserved tissue analysis.American journal of cancer research · 2026Article
- Soft elastomeric optical fibers for oxygen change measurements of blood and living tissues: a thermoplastic polyurethane assessment.Biomedical optics express · 2025Article
- Unveiling the Molecular Secrets: A Comprehensive Review of Raman Spectroscopy in Biological Research.ACS omega · 2024Review
- Species identification and strain discrimination of fermentation yeastsApplied and environmental microbiology · 2023Article
- Label-Free Human Disease Characterization through Circulating Cell-Free DNA Analysis Using Raman Spectroscopy.International journal of molecular sciences · 2023Article
- Review
- Automated analysis of microplastics based on vibrational spectroscopy: are we measuring the same metrics?Analytical and bioanalytical chemistry · 2022Article
- Raman Spectroscopy: A Novel Technology for Gastric Cancer Diagnosis.Frontiers in bioengineering and biotechnology · 2022Review
- Raman spectral cytopathology for cancer diagnostic applications.Nature protocols · 2021Article
- Raman Spectroscopy of Liquid-Based Cervical Smear Samples as a Triage to Stratify Women Who Are HPV-Positive on Screening.Cancers · 2021Article
- Article
- Raman Microspectroscopic Investigation and Classification of Breast Cancer Pathological Characteristics.Molecules (Basel, Switzerland) · 2021Article
- Indication of high lipid content in epithelial-mesenchymal transitions of breast tissues.Scientific reports · 2021Article
- Single Cell Label-Free Probing of Chromatin Dynamics During B Lymphocyte Maturation.Frontiers in cell and developmental biology · 2021Article
- TemporalACS omega · 2020Article
- Raman-Enhanced Spectroscopy (RESpect) Probe for Childhood Non-Hodgkin Lymphoma.SciMedicine journal · 2020Article
- Rapid and complete paraffin removal from human tissue sections delivers enhanced Raman spectroscopic and histopathological analysis.The Analyst · 2020Article
- Raman spectroscopy combined with multivariate analysis to study the biochemical mechanism of lung cancer microwave ablation.Biomedical optics express · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Near-infrared Raman spectroscopy is a powerful analytical tool for detecting critical differences in biological samples with minimum interference in the Raman spectra from the native fluorescence of the samples. The technique is often suggested as a potential screening tool for cancer. In this article we report in vitro Raman spectra of squamous cells in normal and cancerous cervical human tissue from seven patients, which have good signal-to-noise ratio and which were found to be reproducible. These preliminary results show that several Raman features in these spectra could be used to distinguish cancerous cervical squamous cells from normal cervical squamous cells. In general, the Raman spectra of cervical cancer cells show intensity differences compared to those of normal squamous cell spectra. For example, several well-defined Raman peaks of collagen in the 775 to 975 cm(-1) region are observed in the case of normal squamous cells, but these are below the detection limit of normal Raman spectroscopy in the spectra of invasive cervical cancer cells. In the high frequency 2800 to 3100 cm(-1) region, it is found that the peak area under the CH stretching band is lower by a factor of approximately six in the spectra of cervical cancer cells as compared with that of the normal cells. The Raman chemical maps of regions of cancer and normal cells in the cervical epithelium made from the spectral features in the 775 to 975 cm(-1) and 2800 to 3100 cm(-1) regions are also found to show good correlation with each other.
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