ArticleBMC medical genetics2010
Variants of the Matrix Metalloproteinase-2 but not the Matrix Metalloproteinase-9 genes significantly influence functional outcome after stroke.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- The Role of Biomarkers in Atherothrombotic Stroke-A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Influences of genetic variants on stroke recovery: a meta-analysis of the 31,895 cases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Pooled it
- Association between the MMP-9-1562 C>T polymorphism and the risk of stroke: a meta-analysis.Molecular biology reports · 2014Pooled it
- Genetics of ischemic stroke functional outcome.Journal of neurology · 2024Review
- The roles of MMP8/MMP10 polymorphisms in ischemic stroke susceptibility.Brain and behavior · 2022Article
- MMP9 SNP and MMP SNP-SNP interactions increase the risk for ischemic stroke in the Han Hakka population.Brain and behavior · 2022Article
- Correlation between matrix metalloproteinase-2 polymorphisms and first and recurrent atherosclerotic ischemic stroke events: a case-control study.The Journal of international medical research · 2021Article
- Correlation of molecular biomarker concentrations between synovial fluid and saliva of the patients with temporomandibular disorders.Clinical oral investigations · 2020Article
- Relationship between the matrix metalloproteinase-9 gene polymorphisms and ischemic stroke.International journal of clinical and experimental pathology · 2019Article
- Matrix metalloproteinase-2 gene polymorphisms are associated with ischemic stroke in a Hainan population.Medicine · 2018Observational
- Association of SNPs in the TIMP-2 gene and large artery atherosclerotic stroke in southern Chinese Han population.Oncotarget · 2018Article
- DNA Methylation in Stroke. Update of Latest Advances.Computational and structural biotechnology journal · 2018Review
- Observational
- A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head.Oncotarget · 2016Article
- The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke.International journal of molecular sciences · 2016Review
- Electroacupuncture ameliorates post-stroke learning and memory through minimizing ultrastructural brain damage and inhibiting the expression of MMP-2 and MMP-9 in cerebral ischemia-reperfusion injured rats.Molecular medicine reports · 2016Article
- Expression and Activity of Metalloproteinases in Depression.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Inflammatory and metabolic markers and short-time outcome in patients with acute ischemic stroke in relation to TOAST subtypes.Metabolic brain disease · 2015Article
- Matrix Metalloproteinase-9 (MMP-9) Gene Polymorphism in Stroke Patients.Neuromolecular medicine · 2015Article
- Tumor necrosis factor beta NcoI polymorphism (rs909253) is associated with inflammatory and metabolic markers in acute ischemic stroke.Metabolic brain disease · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple lines of evidence suggest that genetic factors contribute to stroke recovery. The matrix metalloproteinases -2 (MMP-2) and -9 (MMP-9) are modulators of extracellular matrix components, with important regulatory functions in the Central Nervous System (CNS). Shortly after stroke, MMP-2 and MMP-9 have mainly damaging effects for brain tissue. However, MMPs also have a beneficial activity in angiogenesis and neurovascular remodelling during the delayed neuroinflammatory response phase, thus possibly contributing to stroke functional recovery.
methodsIn the present study, the role of MMP-2 and MMP-9 genetic variants in stroke recovery was investigated in 546 stroke patients. Functional outcome was assessed three months after a stroke episode using the modified Rankin Scale (mRS), and patients were classified in two groups: good recovery (mRS </= 1) or poor recovery (mRS>1). Haplotype tagging single nucleotide polymorphisms (SNPs) in the MMP-2 (N = 21) and MMP-9 (N = 4) genes were genotyped and tested for association with stroke outcome, adjusting for significant non-genetic clinical variables.
resultsSix SNPs in the MMP-2 gene were significantly associated with stroke outcome (0.0018<P < 0.0415), two of which survived the Bonferroni correction for multiple testing. In the subset of ischemic stroke patients, association of five of these SNPs remained positive (0.0042<P < 0.0306). No significant associations were found for the MMP-9 gene.
conclusionsThe results presented strongly indicate that MMP-2 genetic variants are an important mediator of functional outcome after stroke.
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