ArticleWorld journal of gastroenterology2010
Heme oxygenase-1 protects donor livers from ischemia/reperfusion injury: the role of Kupffer cells.
Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments.Aging and disease · 2022Review
- Isoflurane upregulates microRNA-9-3p to protect rats from hepatic ischemia-reperfusion injury through inhibiting fibronectin type III domain containing 3B.Cell cycle (Georgetown, Tex.) · 2021Article
- Protective role of heme oxygenase-1 in fatty liver ischemia-reperfusion injury.Medical molecular morphology · 2019Review
- Protective Effects of Apoptosis of Kupffer Cells Induced by Zoledronate Liposomes Following Hepatic Ischemia-Reperfusion Injury.Annals of transplantation · 2018Article
- The Protective Effect of Heme Oxygenase-1 against Intestinal Barrier Dysfunction in Cholestatic Liver Injury Is Associated with NF-κB Inhibition.Molecular medicine (Cambridge, Mass.) · 2017Article
- New progress in roles of nitric oxide during hepatic ischemia reperfusion injury.World journal of gastroenterology · 2017Review
- Mechanism of Hepatocyte Apoptosis.Journal of cell death · 2016Review
- Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways.World journal of gastroenterology · 2015Article
- Octreotide attenuates liver fibrosis by inhibiting hepatic heme oxygenase-1 expression.Molecular medicine reports · 2015Article
- Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation.World journal of gastroenterology · 2013Article
- Influence of Kupffer cells and platelets on ischemia-reperfusion injury in mild steatotic liver.World journal of gastroenterology · 2013Article
- Diazoxide attenuates ischemia/reperfusion injury via upregulation of heme oxygenase-1 after liver transplantation in rats.World journal of gastroenterology · 2012Article
- Heme oxygenase-1 prevents liver fibrosis in rats by regulating the expression of PPARγ and NF-κB.World journal of gastroenterology · 2012Article
- Article
- Cell biology of ischemia/reperfusion injury.International review of cell and molecular biology · 2012Review
- Dual protective role of HO-1 in transplanted liver grafts: a review of experimental and clinical studies.World journal of gastroenterology · 2011Review
- Heme oxygenase system in hepatic ischemia-reperfusion injury.World journal of gastroenterology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
aimTo examine whether heme oxygenase (HO)-1 overexpression would exert direct or indirect effects on Kupffer cells activation, which lead to aggravation of reperfusion injury.
methodsDonors were pretreated with cobalt protoporphyrin (CoPP) or zinc protoporphyrin (ZnPP), HO-1 inducer and antagonist, respectively. Livers were stored at 4 degrees C for 24 h before transplantation. Kupffer cells were isolated and cultured for 6 h after liver reperfusion.
resultsPostoperatively, serum transaminases were significantly lower and associated with less liver injury when donors were pretreated with CoPP, as compared with the ZnPP group. Production of the cytokines tumor necrosis factor-alpha and interleukin-6 generated by Kupffer cells decreased in the CoPP group. The CD14 expression levels (RT-PCR/Western blots) of Kupffer cells from CoPP-pretreated liver grafts reduced.
conclusionThe study suggests that the potential utility of HO-1 overexpression in preventing ischemia/reperfusion injury results from inhibition of Kupffer cells activation.
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Registered trials
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