ReviewDevelopmental psychobiology2010
The storm and stress of adolescence: insights from human imaging and mouse genetics.
Review in Developmental psychobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 194 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
194 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Adolescent Loneliness When a Parent Has Cancer: A Qualitative Systematic Review.Psycho-oncology · 2025Pooled it
- The impact of the pandemic on psychophysical well-being and quality of learning in the growth of adolescents (aged 11-13): a systematic review of the literature with a PRISMA method.Frontiers in psychology · 2024Pooled it
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- A Systematic Review of MRI Neuroimaging for Education Research.Frontiers in psychology · 2021Pooled it
- Structural and Functional Neural Targets of Addiction Treatment in Adolescents and Young Adults: A Systematic Review and Meta-Analysis.Journal of child and adolescent psychopharmacology · 2019Pooled it
- Associations of Coping Strategies With Glycemic and Psychosocial Outcomes Among Adolescents With Type 1 Diabetes Experiencing Diabetes Distress.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024Trial
- Closed-loop digital meditation for neurocognitive and behavioral development in adolescents with childhood neglect.Translational psychiatry · 2020Trial
- Age-related differences in emotional reactivity, regulation, and rejection sensitivity in adolescence.Emotion (Washington, D.C.) · 2012Trial
- Enhanced right amygdala activity in adolescents during encoding of positively valenced pictures.Developmental cognitive neuroscience · 2011Trial
- A Neurodevelopmental Model of Social Threat Sensitivity as a Mechanism Linking Fearful Temperament, Social Anxiety, and Depression in Youth.Journal of child and adolescent psychopharmacology · 2026Review
- Emotion Regulation Strategies Related To Problem Behaviors in Teenagers: A Latent Profile Analysis.The Psychiatric quarterly · 2026Article
- Normative scores and clinical cut-offs of the Cyclothymic-Hypersensitive Temperament Questionnaire in adolescence.JCPP advances · 2026Article
- Developmental trajectories of vocabulary and logical thinking skills across adolescence: a person-centered longitudinal study in China.BMC public health · 2026Article
- Article
- Tracing pathways: the impact of the polycrisis on mental health trajectories in emerging adulthood.Frontiers in public health · 2026Article
- Developmental Change in Cognitive Emotion Regulation Profiles in the Transition from Childhood to Adolescence.Research on child and adolescent psychopathology · 2025Article
- Examining Causal Pathways to Suicidal Ideation and Nonsuicidal Self-Injury in the Adolescent Brain Cognitive Development Study.Suicide & life-threatening behavior · 2025Article
- The Validity and Reliability of the Short Form of the Adolescent Stress Questionnaire (ASQ-14) Among Greek Adolescents Aged 15-18.Children (Basel, Switzerland) · 2025Article
- Influence of early life adversity and breed on aggression and fear in dogs.Scientific reports · 2025Article
- Risk and resilience profiles and their transition pathways in the ABCD Study.Development and psychopathology · 2025Article
134 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The characterization of adolescence as a time of "storm and stress" remains an open debate. Intense and frequent negative affect during this period has been hypothesized to explain the increased rates of affective disorders, suicide, and accidental death during this time of life. Yet some teens emerge from adolescence with minimal turmoil. We provide a neurobiological model of adolescence that proposes an imbalance in the development of subcortical limbic (e.g., amygdala) relative to prefrontal cortical regions as a potential mechanism for heightened emotionality during this period. Empirical support for this model is provided from recent behavioral and human imaging studies on the development of emotion regulation. We then provide examples of environmental factors that may exacerbate imbalances in amygdala-ventrofrontal function increasing risk for anxiety related behaviors. Finally we present data from human and mouse studies to illustrate how genetic factors may enhance or diminish this risk. Together, these studies provide a converging methods approach for understanding the highly variable stress and turmoil experienced in adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.