ArticleThe EMBO journal1991
Insulin stimulation of gene expression mediated by p21ras activation.
Article in The EMBO journal, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 284 citations in OpenAlex.
- Diabetes mellitus is an independent risk factor for colorectal cancer.Digestive diseases and sciences · 2012Pooled it
- Review
- Role of insulin action in the pathogenesis of diabetic complications.Diabetology international · 2022Review
- Functional characterisation of a novel class of in-frame insertion variants of KRAS and HRAS.Scientific reports · 2019Article
- From Ras to Rap and Back, a Journey of 35 Years.Cold Spring Harbor perspectives in medicine · 2018Review
- Data of rational process optimization for the production of a full IgG and its Fab fragment from hybridoma cells.Data in brief · 2016Article
- FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression.EMBO reports · 2015Article
- Effect of bombesin receptor subtype-3 and its synthetic agonist on signaling, glucose transport and metabolism in myocytes from patients with obesity and type 2 diabetes.International journal of molecular medicine · 2015Article
- Circulating concentrations of C-Peptide and colorectal adenoma.Clinical nutrition research · 2014Article
- Roles of hormones and signaling molecules in describing the relationship between obesity and colon cancer.Pathology oncology research : POR · 2011Review
- AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B.Oncogene · 2009Article
- Particle image correlation spectroscopy (PICS): retrieving nanometer-scale correlations from high-density single-molecule position data.Biophysical journal · 2007Article
- Direct control of caveolin-1 expression by FOXO transcription factors.The Biochemical journal · 2005Article
- Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Hyperinsulinaemia and hyperglycaemia: possible risk factors of colorectal cancer among diabetic patients.Diabetologia · 2003Review
- Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.The EMBO journal · 2002Article
- Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway.Molecular and cellular biology · 2000Article
- Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts.The Journal of biological chemistry · 2000Article
- Interferon-alpha2b reduces phosphorylation and activity of MEK and ERK through a Ras/Raf-independent mechanism.British journal of cancer · 2000Article
- Molecular mechanisms of contraction-regulated cardiac glucose transport.The Biochemical journal · 2000Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In fibroblasts, insulin is a weak mitogen and does not induce expression of c-fos, c-jun or p33. However, increasing the expression levels of either normal p21Hras or the insulin receptor, but not mutant p21Hras, enables insulin to induce the expression of these genes. In cells expressing elevated levels of insulin receptor, this process involves a rapid increase in p21rasGTP levels (from 20% to 70% GTP as a percentage of total guanine nucleotides). No increase in p21rasGTP levels was observed after PDGF and EGF stimulation of cells expressing high levels of the cognate receptor, stressing the specificity of the insulin-induced increase. We conclude that in fibroblasts, p21ras is an intermediate of the insulin signal transduction pathway involved in the regulation of gene expression and mitogenicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.