Evidence map›Paper›PMID 20221773›Full record

Trial reportEuropean journal of applied physiology2010

The limit to exercise tolerance in humans: mind over muscle?

Samuele Maria Marcora, Walter Staiano

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 141 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effectiveness of Nitrate Intake on Recovery from Exercise-Related Fatigue: A Systematic Review.International journal of environmental research and public health · 2022
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  19. Pacing strategies during repeated maximal voluntary contractions.European journal of applied physiology · 2014
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81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Samuele Maria MarcoraSchool of Sport, Health and Exercise Sciences, Bangor University, Normal Site, Holyhead Road, Bangor, Gwynedd LL57 2PZ, Wales, UK. s.m.marcora@bangor.ac.uk
Walter Staiano

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In exercise physiology, it has been traditionally assumed that high-intensity aerobic exercise stops at the point commonly called exhaustion because fatigued subjects are no longer able to generate the power output required by the task despite their maximal voluntary effort. We tested the validity of this assumption by measuring maximal voluntary cycling power before (mean +/- SD, 1,075 +/- 214 W) and immediately after (731 +/- 206 W) (P < 0.001) exhaustive cycling exercise at 242 +/- 24 W (80% of peak aerobic power measured during a preliminary incremental exercise test) in ten fit male human subjects. Perceived exertion during exhaustive cycling exercise was strongly correlated (r = -0.82, P = 0.003) with time to exhaustion (10.5 +/- 2.1 min). These results challenge the long-standing assumption that muscle fatigue causes exhaustion during high-intensity aerobic exercise, and suggest that exercise tolerance in highly motivated subjects is ultimately limited by perception of effort.

Indexed as

ExerciseExercise ToleranceMotivationMuscle ContractionMuscle FatigueMuscle, SkeletalMuscle StrengthPerceptionBicyclingHeart RateHumansLactic AcidMaleModels, PsychologicalOxygen ConsumptionReproducibility of ResultsLactic Acid

Identifiers

PMID20221773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.