SynthesisClinical research in cardiology : official journal of the German Cardiac Society2010
Drug-eluting stents in acute myocardial infarction: updated meta-analysis of randomized trials.
Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01684982 (Randomized Comparison of Everolimus Eluting Stents and Sirolimus Eluting Stent in Patients With ST Elevation Myocardial Infarction), which is not on this map. Cited by 13 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Comparison of Everolimus Eluting Stents and Sirolimus Eluting Stent in Patients With ST Elevation Myocardial Infarction (STEMI) (RaCES-MI Trial)
Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Paclitaxel-eluting versus bare metal stents in primary PCI: a pooled patient-level meta-analysis of randomized trials.Journal of thrombosis and thrombolysis · 2015Pooled it
- Long-term outcomes of drug-eluting versus bare-metal stent for ST-elevation myocardial infarction.Arquivos brasileiros de cardiologia · 2014Pooled it
- Long-term clinical outcomes following sirolimus-eluting stent implantation in patients with acute myocardial infarction. A meta-analysis of randomized trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Pooled it
- Everolimus-eluting versus sirolimus-eluting stents: an updated meta-analysis of randomized trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Pooled it
- Rapamycin unbalances the polarization of human macrophages to M1.Immunology · 2013Trial
- Efficacy and Safety of TiNO-Coated Stents versus Drug-Eluting Stents in Acute Coronary Syndrome: Systematic Literature Review and Meta-Analysis.Biomedicines · 2022Review
- Use of drug-eluting stents in acute myocardial infarction with persistent ST-segment elevation: results of the ALKK PCI-registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- The use of drug-eluting stents in acute myocardial infarction - is the battle coming to an end? From despair to acceptance.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2013Review
- Real-world experience of drug-eluting stents in saphenous vein grafts compared to native coronary arteries: results from the prospective multicenter German DES.DE registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Article
- Long-term outcome after drug-eluting stent implantation in comparison with bare metal stents: a single centre experience.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Drug-eluting versus bare-metal stents in ST-segment elevation myocardial infarction: a mortality analysis from the EUROTRANSFER Registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Article
- Long-term effectiveness and safety of sirolimus drug-eluting stents.Medical devices (Auckland, N.Z.) · 2011Article
- Best way to revascularize patients with main stem and three-vessel lesions. Patients should be operated!Clinical research in cardiology : official journal of the German Cardiac Society · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 12 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUse of drug-eluting stents in patients with acute myocardial infarction (AMI) remains an "off label" indication due to concerns regarding their performance in this patient subset.
methodsWe searched Medline, the Cochrane Central Register of Controlled Trials, and Internet-based sources of information on clinical trials in cardiology for randomized trials comparing drug-eluting stents with bare-metal stents in patients with AMI. Hazard ratios for the composite of death or recurrent myocardial infarction, (primary safety endpoint), reintervention (primary efficacy endpoint), death, recurrent myocardial infarction, and stent thrombosis were calculated performing a meta-analysis of 14 randomized trials with 7,781 patients.
resultsThere was no difference in the hazard of death or recurrent myocardial infarction (hazard ratio, 0.91; [95% CI 0.75-1.09]) between patients treated with drug-eluting stents versus patients treated with bare-metal stents. Treatment with drug-eluting stents resulted in a significant reduction in the hazard of reintervention (0.41 [95% CI 0.32-0.52]). The hazards of death (0.90 [95% CI 0.71-1.15]), myocardial infarction (0.81 [95% CI 0.63-1.04]), and stent thrombosis (0.84 [95% CI 0.61-1.17]) were not significantly different between patients treated with drug-eluting stents versus patients treated with bare-metal stents.
conclusionsUse of drug-eluting stents in patients with AMI is safe and markedly reduces the need for reintervention as compared to bare-metal stents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.