ArticleDose-response : a publication of International Hormesis Society2009
Prospectus. Survival across the fitness-stress continuum under the ecological stress theory of aging: caloric restriction and ionizing radiation.
Article in Dose-response : a publication of International Hormesis Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Study logistics that can impact medical countermeasure efficacy testing in mouse models of radiation injury.International journal of radiation biology · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Free living organisms typically occur in harsh environments challenged by abiotic stresses of varying intensities. Taking ionizing radiation and caloric restriction as examples, environmental variation from benign to extreme gives a fitness-stress continuum where energetic efficiency, a measure of fitness, is inversely related to stress level. Hormesis occurs in benign regions for these examples. In contrast aging emphasizes survival towards the limits of survival under accumulating stress from Reactive Oxygen Species, ROS. An energetic evolutionary approach underlies an ecological aging theory based principally upon survival, which incorporates hormesis. Multiple environmental agents contributing to hormesis should be considered by those attempting to improve the quality of life by delaying the onset of senescence, so enhancing survival. Caloric restriction has wider acceptance in this process than ionizing radiation.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.