ArticleNature2010
A computational model of teeth and the developmental origins of morphological variation.
Article in Nature, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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Who cites it
125 citing papers in PubMed, 335 citations in OpenAlex.
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- Color patterns as a model for connecting developmental mechanisms to phenotypic evolution.Nature communications · 2026Review
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- Lateral inhibition governs ancestral cellular patterning in fossil and extant liverworts.Development (Cambridge, England) · 2026Article
- Bridging developmental and statistical approaches to variation and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tooth-on-a-chip to engineer early dental epithelial-mesenchymal interaction.Materials today. Bio · 2025Article
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- A simple model reveals why complex evolutionary innovations follow predictable paths.bioRxiv : the preprint server for biology · 2025Article
- Bounding phenotype transition probabilities via conditional complexity.Journal of the Royal Society, Interface · 2025Article
- The structure of an ancient genotype-phenotype map shaped the functional evolution of a protein family.Nature ecology & evolution · 2025Article
- Six million years of vole dental evolution shaped by tooth development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Deep origins, distinct adaptations, and species-level status indicated for a glacial relict seal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cap-to-bell stage molar tooth morphogenesis occurs through proliferation-independent sulcus sharpening and condensation-associated tension in the dental papilla.Journal of anatomy · 2025Article
- The structure of an ancient genotype-phenotype map shaped the functional evolution of a protein family.bioRxiv : the preprint server for biology · 2025Article
- The next generation of regenerative dentistry: From tooth development biology to periodontal tissue, dental pulp, and whole tooth reconstruction in the clinical setting.Regenerative therapy · 2025Review
- Developmental basis of natural tooth shape variation in cichlid fishes.Die Naturwissenschaften · 2025Article
- Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation.Nature communications · 2025Article
- Simulating macroevolutionary trends and open-ended evolution with a novel mechanistic multi-level approach.PloS one · 2025Article
- The legacy and evolvability of Pere Alberch's ideas.Interface focus · 2024Article
- Notum regulates the cusp and root patterns in mouse molar.Scientific reports · 2024Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between the genotype and the phenotype, or the genotype-phenotype map, is generally approached with the tools of multivariate quantitative genetics and morphometrics. Whereas studies of development and mathematical models of development may offer new insights into the genotype-phenotype map, the challenge is to make them useful at the level of microevolution. Here we report a computational model of mammalian tooth development that combines parameters of genetic and cellular interactions to produce a three-dimensional tooth from a simple tooth primordia. We systematically tinkered with each of the model parameters to generate phenotypic variation and used geometric morphometric analyses to identify, or developmentally ordinate, parameters best explaining population-level variation of real teeth. To model the full range of developmentally possible morphologies, we used a population sample of ringed seals (Phoca hispida ladogensis). Seal dentitions show a high degree of variation, typically linked to the lack of exact occlusion. Our model suggests that despite the complexity of development and teeth, there may be a simple basis for dental variation. Changes in single parameters regulating signalling during cusp development may explain shape variation among individuals, whereas a parameter regulating epithelial growth may explain serial, tooth-to-tooth variation along the jaw. Our study provides a step towards integrating the genotype, development and the phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.