ArticlePediatric research2010
The Rho pathway mediates transition to an alveolar type I cell phenotype during static stretch of alveolar type II cells.
Article in Pediatric research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Idiopathic pulmonary fibrosis from a multiscale mechanobiology perspective: Mechanisms and future therapeutic prospects.iScience · 2026Review
- Mechanotransduction: A Master Regulator of Alveolar Cell Fate Determination.Bioengineering (Basel, Switzerland) · 2025Review
- Alveolar epithelial paxillin in postnatal lung alveolar development.Biology open · 2025Article
- Rational engineering of lung alveolar epithelium.NPJ Regenerative medicine · 2023Article
- Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling.Nature communications · 2022Article
- Lung Extracellular Matrix Hydrogels Enhance Preservation of Type II Phenotype in Primary Alveolar Epithelial Cells.International journal of molecular sciences · 2022Article
- Review
- Article
- Automated cell-type classification in intact tissues by single-cell molecular profiling.eLife · 2018Article
- Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?The Journal of pediatrics · 2017Review
- Expression of surfactant protein B is dependent on cell density in H441 lung epithelial cells.PloS one · 2017Article
- Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner.Scientific reports · 2015Article
- Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase.The FEBS journal · 2014Article
- Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-β and BMP signaling.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Interfacial stress affects rat alveolar type II cell signaling and gene expression.American journal of physiology. Lung cellular and molecular physiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Stretch is an essential mechanism for lung growth and development. Animal models in which fetal lungs have been chronically over or underdistended demonstrate a disrupted mix of type II and type I cells, with static overdistention typically promoting a type I cell phenotype. The Rho GTPase family, key regulators of cytoskeletal signaling, are known to mediate cellular differentiation in response to stretch in other organs. Using a well-described model of alveolar epithelial cell differentiation and a validated stretch device, we investigated the effects of supraphysiologic stretch on human fetal lung alveolar epithelial cell phenotype. Static stretch applied to epithelial cells suppressed type II cell markers (SP-B and Pepsinogen C, PGC), and induced type I cell markers (Caveolin-1, Claudin 7 and Plasminogen Activator Inhibitor-1, PAI-1) as predicted. Static stretch was also associated with Rho A activation. Furthermore, the Rho kinase inhibitor Y27632 decreased Rho A activation and blunted the stretch-induced changes in alveolar epithelial cell marker expression. Together these data provide further evidence that mechanical stimulation of the cytoskeleton and Rho activation are key upstream events in mechanotransduction-associated alveolar epithelial cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.