ArticleAnnals of Saudi medicine
Candidal colonization, strain diversity, and antifungal susceptibility among adult diabetic patients.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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28 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Oral microbiome alterations in individuals with type 1 diabetes: a systematic review.Clinical oral investigations · 2026Pooled it
- Host-pathogen interactions in periodontitis: an integrative interkingdom perspective.Frontiers in immunology · 2026Review
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- Metabolic Plasticity and Virulence-Associated Factors ofJournal of fungi (Basel, Switzerland) · 2023Article
- Infectious diseases associated with pediatric type 1 diabetes mellitus: A narrative review.Frontiers in endocrinology · 2022Review
- Clinico-Cytological Study of Fungal Elements in the Buccal Smears of Prediabetic, Diabetic, and Nondiabetic Individuals in Association with Burning Sensation.Journal of pharmacy & bioallied sciences · 2021Article
- Challenges in Antifungal Therapy in Diabetes Mellitus.Journal of clinical medicine · 2020Article
- A Case-Control Study to Evaluate Candidal Parameters in the Oral Cavity of Patients with Type 2 Diabetes Mellitus.Journal of pharmacy & bioallied sciences · 2020Article
- Oropharyngeal Candida Colonization in Patients with Acute Myeloid Leukemia.Frontiers in dentistry · 2020Article
- Oral Prevalence ofInfection and drug resistance · 2020Article
- Fungal Infection among Diabetic and Nondiabetic Individuals in Nepal.Interdisciplinary perspectives on infectious diseases · 2020Article
- Estimation and correlation of serum and salivary glucose and immunoglobulin A levels and salivary candidal carriage in diabetic and non-diabetic patients.Journal of dental research, dental clinics, dental prospects · 2020Article
- An alarming rise of non-albicans Candida species and uncommon yeasts in the clinical samples; a combination of various molecular techniques for identification of etiologic agents.BMC research notes · 2019Article
- Oral Candidal carriage and associated risk indicators among adults in Sakaka, Saudi Arabia.BMC oral health · 2019Article
- Candida sp. Infections in Patients with Diabetes Mellitus.Journal of clinical medicine · 2019Review
- Subgingival areas as potential reservoirs of different Candida spp in type 2 diabetes patients and healthy subjects.PloS one · 2019Observational
- Article
- Drug interactions of meglitinide antidiabetics involving CYP enzymes and OATP1B1 transporter.Therapeutic advances in endocrinology and metabolism · 2018Review
- Occurrence of oral Candida colonization and its risk factors among patients with malignancies in China.Clinical oral investigations · 2016Observational
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesCandidal colonization in diabetics is a matter of debate. The aim of this study is to investigate oral candidal colonization, strain diversity, antifungal susceptibility, and the influence of local and systemic host factors on candidal colonization in adult diabetics.
methodsWe conducted a case-control study that compared 150 diabetics (49 type 1, 101 type 2) with 50 healthy controls. Two salivary samples were collected, using the oral rinse sampling method: one for salivary flow rate and pH determination, and the other for candidal colonization assessment. The candidal isolates were identified and tested in vitro for antifungal susceptibility using the commercial kit, Candifast. The relationship between specific host factors and candidal colonization was also investigated.
resultsDiabetics had a higher candidal carriage rate compared to controls, but not density. Candida albicans was the most frequently isolated species, but diabetics had a variety of other candidal species present. None of the control samples were resistant to any tested antifungal, while the diabetic samples had differing resistances to azole antifungals. Although there was a significant positive correlation between glycemic control and candidal colonization in type 2 diabetics, there was a negative correlation between salivary pH and candidal carriage in the controls versus density in type 2 diabetics.
conclusionsDiabetic patients not only had a higher candidal carriage rate, but also a variety of candidal species that were resistant to azole antifungals. Oral candidal colonization was significantly associated with glycemic control, type of diabetes, and salivary pH.
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