Trial reportThe Journal of nutrition2010
Choline intake exceeding current dietary recommendations preserves markers of cellular methylation in a genetic subgroup of folate-compromised men.
Trial report in The Journal of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Trial
- Article
- Epigenetic Modifications and Their Potential Contribution to Traumatic Brain Injury Pathobiology and Outcome.Journal of neurotrauma · 2022Review
- Review
- Maternal Choline Supplementation and High-Fat Feeding Interact to Influence DNA Methylation in Offspring in a Time-Specific Manner.Frontiers in nutrition · 2022Article
- The Effects of Dietary Interventions on DNA Methylation: Implications for Obesity Management.International journal of molecular sciences · 2020Review
- Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype.European journal of nutrition · 2018Article
- Folate promotes S-adenosyl methionine reactions and the microbial methylation cycle and boosts ruminants production and reproduction.AMB Express · 2018Review
- Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements.Nutrients · 2017Review
- High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study.Environmental and molecular mutagenesis · 2017Article
- Implications of DNA Methylation in Parkinson's Disease.Frontiers in molecular neuroscience · 2017Review
- Effects of Choline on DNA Methylation and Macronutrient Metabolic Gene Expression in In Vitro Models of Hyperglycemia.Nutrition and metabolic insights · 2016Article
- Biomarkers of Nutrition for Development-Folate Review.The Journal of nutrition · 2015Review
- Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the Women's Health Initiative Observational Study cohort.Epigenetics · 2014Observational
- Choline and betaine intakes are associated with reduced risk of nasopharyngeal carcinoma in adults: a case-control study.British journal of cancer · 2014Article
- Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.Clinical chemistry and laboratory medicine · 2013Review
- S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells.Molecular and clinical oncology · 2013Article
- Nutrition in pregnancy: the argument for including a source of choline.International journal of women's health · 2013Article
- Choline nutrition programs brain development via DNA and histone methylation.Central nervous system agents in medicinal chemistry · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Severe choline deficiency adversely affects cellular methylation and DNA integrity, with potentially serious implications for disease risk. As part of a 12-wk controlled choline intervention study conducted in folate-compromised Mexican-American men (n = 60; 18-55 y) differing in the methylenetetrahydrofolate reductase (MTHFR) C677T genotype (21 677CC, 29 677TT), this study evaluated the effects of varied choline intakes (300, 550, 1100, and 2200 mg/d) on the change (i.e. wk 12-0) in markers of cellular methylation and DNA integrity. Choline intake affected the change in plasma S-adenosylmethionine (P = 0.044), with decreases tending to be greater (P < or = 0.08) in the 300 and 550 mg/d groups than in the 2200 mg/d group. Choline intake also interacted with the MTHFR C677T genotype to affect the change in genomic DNA methylation and DNA damage. In men with the MTHFR 677CC genotype, choline intake affected (P = 0.007) the change in DNA methylation, with a greater decrease (P < 0.02) in the 300 mg/d group than in the 1100 and 2200 mg/d groups. In men with the MTHFR 677CC genotype, choline intake also affected (P = 0.047) the change in DNA damage, with the increase tending to be greater (P = 0.07) in the 550 mg/d group than in the 2200 mg/d group. Choline intake did not affect these variables in men with the MTHFR 677TT genotype. Overall, these data suggest that choline intake exceeding current dietary recommendations preserves markers of cellular methylation and attenuates DNA damage in a genetic subgroup of folate-compromised men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.