ArticleJournal of clinical microbiology2010
Citrobacter spp. simultaneously harboring blaCTX-M, blaTEM, blaSHV, blaampC, and insertion sequences IS26 and orf513: an evolutionary phenomenon of recent concern for antibiotic resistance.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Silent spreaders: multidrug-resistant and hypermucoviscous Klebsiella from animals threaten one health.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- TheInternational journal of molecular sciences · 2026Review
- Occurrence ofPathogens (Basel, Switzerland) · 2026Article
- Antimicrobial resistance profiles and genomic insights of phenotypically extended spectrum β-lactamase-positive Klebsiella pneumoniae from cattle farms.Current genetics · 2025Article
- Antibiotic resistance profile in sediments and bacterial isolates from a human-impacted mangrove from Bahía Magdalena, Mexico.Sustainable microbiology · 2024Article
- Molecular Screening of Carbapenem-ResistantJournal of clinical medicine · 2023Article
- Genomic epidemiology of nosocomial carbapenemase-producingFrontiers in microbiology · 2023Article
- Bacterial Contamination of Surgical Instruments Used at the Surgery Department of a Major Teaching Hospital in a Resource-Limited Country: An Observational Study.Diseases (Basel, Switzerland) · 2022Article
- Plasmid CarryingInfectious diseases · 2022Article
- Production of extended-spectrum beta-lactamases inBrazilian journal of veterinary medicine · 2022Article
- Emergence of plasmid-mediated colistin resistanceFrontiers in cellular and infection microbiology · 2022Article
- "Occurrence ofSaudi journal of biological sciences · 2021Article
- Antimicrobial Resistance and Cytotoxicity ofFrontiers in microbiology · 2017Article
- Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples.Emerging infectious diseases · 2016Article
- Multidrug Resistance Related to Biofilm Formation in Acinetobacter baumannii and Klebsiella pneumoniae Clinical Strains from Different Pulsotypes.Current microbiology · 2016Article
- Community-Acquired Pneumonia and Empyema Caused by Citrobacter koseri in an Immunocompetent Patient.Case reports in pulmonology · 2015Article
- Species identification of strains belonging to genus Citrobacter using the biochemical method and MALDI-TOF mass spectrometry.Folia microbiologica · 2015Article
- Citrobacter koseri: an unusual cause of pyogenic liver abscess.BMJ case reports · 2013Article
- Concurrent occurrence of blaampC families and blaCTX-M genogroups and association with mobile genetic elements ISEcp1, IS26, ISCR1, and sul1-type class 1 integrons in Escherichia coli and Klebsiella pneumoniae isolates originating from India.Journal of clinical microbiology · 2012Article
- CTX-M-14 β-lactamase-producing Citrobacter freundii isolated in Venezuela.Annals of clinical microbiology and antimicrobials · 2011Article
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Abstract
A collection of 40 confirmed isolates of Citrobacter spp., obtained from the culture of 5,732 clinical samples during 2006 to 2008, was studied for the presence of blaCTX-M, blaTEM, blaSHV, and blaampC by monoplex and multiplex PCRs. These isolates were also looked at for the presence of insertion elements IS26 and orf513, which play an important role in the resistance gene pool. blaCTX-M, blaTEM, blaSHV, and blaampC were noticed in 67.5%, 40%, 25%, and 40% of isolates, respectively. Sequencing for the specific CTX-M type revealed the presence of CTX-M-15-type extended-spectrum beta-lactamases (ESBL). sul1-type integrons were detected in 32.5% (13/40) of isolates, and a single plasmid of ca. approximately 22 kb was also noticed in all the isolates harboring bla genes. A total of 48.2% (13/27) of isolates harboring blaCTX-M alleles were found to carry IS26 elements and 53.4% (7/13) of isolates harboring the sul1-type integrons were found to carry orf513. Alarmingly, a few isolates simultaneously carried IS26 and orf513, reflecting the occurrence of complex evolution. All the Citrobacter isolates were noticed to produce an amplicon of 400 bp in an IS26 PCR, similar to that of the predominant UK CTX-M-15-producing Escherichia coli clone (clone A) and suggesting a probable genetic relatedness between the two, which could not be proved with British and Indian E. coli isolates in our earlier studies. Here, a first report is being presented describing the occurrence of blaCTX-M-15 in Indian Citrobacter spp. This is also the first report describing the simultaneous occurrence of blaTEM, blaSHV, and blaampC along with blaCTX-M in class 1 integrons. The recent findings indicate that the genetic environment of blaCTX-M-15 has changed through the insertion of IS26 and orf513, although the consequences of these events remain uncertain. It perhaps also suggests a "turnover" of these mobile elements in the population over time.
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